Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Drugs of Abuse
Drugs of Abuse - Pharm
| Question | Answer |
|---|---|
| Positive Reinforcement = ? | * Animal does something, and get a reward with a drug directly in to the brain.... * Spot for reward pathway = nucleus accumbens and VTA |
| Neurotransmitter released during + reinforcement at the Nucleus Accumbens and VTA = ? | * Dopamine.... * targeting the mesolimbic pathways |
| Some circuits involved with activation of the Nucleus Accumbens and VTA = ? | * mvt, judgement, reward, memory, coordination ,vision and sensations |
| Even after successful withdrawal and prolonged drug-free periods, addicts are at a high risk of ? | * Relapse |
| Pharmacokinetic Tolerance = ? | * Reduction of [drug] OR shorter duration of action in a target system--- Have to take more drug to get same effect after awhile |
| Pharmacodynamic Tolerance = ? | * Change in receptor function (desensitization and receptor internalization) |
| Cross-Tolerance = ? | * people tolerant to one drug in a class are likely going to be tolerant to other drugs in the same class |
| Fastest way to get a cocaine high (snort or smoke?) ? | * Smoking has a faster high (IV is still slightly faster) |
| Gi/o-coupled receptor drugs = ? | * Opioids, cannabinoids, gamma-hydroxybutyrate, hallucinogens |
| Ionotropic receptors or ion channel drugs = ? | * Nicotine, alcohol, benzodiazepines, dissociative anesthetics, some inhalants |
| Monoamine transporter activation drugs = ? | * Cocaine, amphetamines, ecstasy |
| These drugs alter perception WITHOUT causing sensations of reward and euphoria = ? | * Non-addictive Drugs of Abuse |
| Non-addictive Drugs of Abuse and their MoA = ? | * Lysergic acid diethylamide (LSD) – activates serotonin receptors in the PFC .....* Phencyclidine (PCP) and Ketamine – inhibition of the glutamate NMDA receptor..... * Gamma-hydroxybuturate (GHB) |
| Drug that exceeds all other forms of addiction = ? | * Nicotine = Selective agonist of the nicotinic acetylcholine receptor (nAchR) |
| Nicotine TmT = ? | * nicotine gum/patch... * Buproprion or Varenicline (a partial nAchR agonist) stops craving |
| Most used drug in the world = ? | * Caffeine.... * Inhibits dopamine release --> causes mild stimulation |
| Benzos MoA and basics = ? | * bind to GABA-a receptors... * need to taper off, no cold turkey |
| Cocaine routes = ? | * injected, inhaled, or smoked |
| Cocaine MoA = ? | * PNS: cocaine inhibits voltage-gated Na+ channels .... * CNS: blocks the reuptake of dopamine, norepinephrine, and serotonin through there respective transporters |
| CNS MoA simplified = ? | * cocaine stops the reuptake of NE in the NE transporters, increasing NE in the synaptic cleft.... * with NE not going back in the NET to be stored, vessicles make more NE (thinking it is depleted) and release more |
| Cocaine on D2 receptors = ? | * Cocaine abuser = fewer dopamine rec available… (due to tolerance) |
| Amphetamine MoA = ? | * reverse the action of dopamine and norepinephrine transporters, enter the cell and interfere with vesicular monoamine transport |
| MoA simplified = ? | * Same effect as Cocaine, different MoA.... * Amphets. get taken up by NET, the cell thinks there is too much NE in the vessicle --> sends NE back out the NET to the synaptic cleft |
| Amphetamine administration = ? | * Taken initially in pill form, but can smoked or injected |
| Ecstasy = ? | * MDMA (mollys).... * MOA: similar to amphetamines, binds to the serotonin transporter increases extracellular serotonin.....* Ravers, cause dehydration and they drink water and get water intox that leads to seizures |
| Cathinones = ? | * Bath Salts = CNS stimulant and can see stuff |
| Gamma-hydroxybutyrate (GHB) | * Pharmacological actions mediated through GABA -B receptor... * Date Rape drug |
| LSD = ? | * No addiction or dependence ..... * Induce perceptual symptoms (i.e.shape and color distortion) |
| Cannabinoids = ? | * THC inhibits presynaptic GABA neurons in the VTA which enhances dopamine neurotransmission |
| **Medical Uses of Marijuana** | . |
| Basics = ? | * Can be recreational, decriminalized, or for medical use |
| Decriminalization = ? | * decriminalization means no prison time or criminal record for first-time possession of a small amount for personal consumption. The conduct is treated like a minor traffic violation |
| Dronabinol = ? | * “Synthetic THC” oral medication = Antiemetic and appetite stimulant (Schedule III) |
| Nabilone = ? | * Oral medication = Antiemetic for cancer chemotherapy (schedule II) |
| Medical Marijuana Uses = ? | * Cancer, Pain, Psych issues, HIV/AIDS, Neurodegenerative Disorders |
Created by:
thamrick800
Popular Medical sets