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Neurotransmitters

PNS Exam 2

QuestionAnswer
ACh (nic) Agonist Nicotine
ACh (nic) Antagonist Curare, Rabies
ACh (nic) Potentiator Acetylcholinesterase inhibitors: Physostigmine, Neostigmine, Nerve gas (irrev.)
ACh (nic) Inhibitor Acetylcholinesterase
ACh (nic) Disease Myasthenia gravis
ACh (musc) Agonist Muscarine
ACh (musc) Antagonist Atropine, Belladonna
ACh (musc) Inhibitor Acetylcholinesterase
ACh nicotinic receptor channel type (non-specific Na+/K+) fEPSP
ACh muscarinic receptor channel type (M1+ M2- M3+) all slow potentials
GABA receptor type GABAa (specific Cl- channels) fIPSP
GABA Agonist GABA
GABA Antagonist Bicuculline, Picrotoxin
GABA Potentiator Benzo-diazapines, Valerian, Barbituates, Valproic acid
GABA Inhibitor GABA T
ACh (musc) Disease Alzheimer's
GABA Disease Epilepsy, Panic Anxiety
GLU receptor type NMDA, AMPA (Na+/Ca++ channel)fEPSP, others
GLU Agonist NMDA, AMPA, others
GLU Antagonist Channel blockers: Ketamine, PCP
GLU Potentiator SP (in nociception models)
GLU Disease Huntington's disease
SP receptor type NK1 (neurokinin1): sEPSP
SP Agonist SP
SP Potentiator Capsaicin
SP Disease Nociception modulation
ENK receptor type Mu, Delta, and Kappa (all g-protein mediated) sIPSP
ENK Agonist Opioids, Morphine, Heroin, Percodan, Oxycotin, ect
ENK Antagonist Naloxone, Narcan
ENK Disease Nociception, analgesia, respiratory depression, euphoria, constipation.
5-HT receptor type 5-HT1,fIPSP 5-HT2B, sEPSP vaso-constriction, platelet aggregation; 5-HT3, fEPSP
5-HT Agonist Lysergic Acid
5-HT Potentiator SSRIs: Prozac, Zoloft, Paxil, Wellbutrin, etc MAO inhibitors: pargyline (Deprenyl, selegiline)
5-HT Inhibitor MAO
5-HT Disease Nociception modulation (descending noxious inhibitory control); Sleep; emotional states; depression
DA receptor type D1, sIPSP; D2, sEPSP, others
DA antagonist Haloperidol (Haldol); Thorazine: antipsychotics
DA Potentiators MAO inhibitors: pargyline (Deprenyl, selegiline) L-DOPA; Amphetamines block reuptake
DA Disease Parkinsons
Created by: schriz069
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