Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Antifungal Pharm
| Question | Answer |
|---|---|
| most important antifungal drug for severe infections ? | * Amp-B |
| Are the mainstays of standard treatment ? | * -Azoles (itra and flu) |
| Amphotericin B spectrum ? | * treats just about everything.... DOC for most severe fungal infections |
| When to use ? | * Systemic use reserved for severe, life-threatening infections |
| MOA of Amp-B ? | * preferentially binds to ergosterol in fungal membranes to punch holes in it |
| Amp B Lipid Formulations ? | * less toxicity and nephrotoxicity, but expensive |
| Amp-B SE's ? | * Nephrotoxicity (constricts afferent arterioles)so monitor kidneys, Hypokalemia , cytokine storm - n/v/f, |
| Flucytosine Spectrum ? | * Narrow spectrum antimycotic - Cryptococcals |
| Flucytosine use ? | * Systemic candidiasis & cryptococcal infections ---Cryptococcal meningitis .... * never used alone, usu w/Amp-B |
| Flucytosine MOA ? | * blocks dUMP/nucleic acid synthesis to make RNA/DNA |
| Flucytosine Side Effects ? | * Bone Marrow Depression, n/v/d, GI mucositis - sores in mouth |
| Antifungal azoles advantages ? | * treatment of systemic fungal infections bc low toxicity |
| Azole disadvantages ? | * Inhibit P450 drug-metabolizing enzymes and can increase the levels of many other drugs |
| Azole MOA ? | * Inhibits fungal cytochrome P450-dependent lanosterol 14-alpha-demethylase, which decreases ergosterol, which disrupts fungal cell membrane |
| Fluconazole usu uses ? | * Coccidioidomycosis, meningitis, cryptococcosis, candidiasis.... * Not aspergillosis |
| Fluconazole bioavailability and drug/drug interactions ? | * Absorption not affected by food or gastric pH.... * Fewer drug interactions than itraconazole.... * Eliminated by kidneys so can be used for UTIs |
| Itraconazole activity ? | * Invasive aspergillosis , Blastomycosis, Cryptococcosis, Histoplasmosis , Suspected fungal infection w/ neutropenic fever , Coccidioidomycosis , Sporotrichosis |
| Itraconazole bioavailability ? | * Requires food and acidic gastric pH for drug solubilization, acid lowering drugs can lower this drugs effectiveness |
| Itraconazole Oral Solution? | * doesnt need an acidic environment.... but causes GI upset....excreted via hepatic system |
| Itraconazole Side Effects ? | * drug/drug interactions, CYP3A4 inhibitor.... * has Negative Ionotropic Effects - Can cause hypertension, hypokalemia, and peripheral edema |
| Voriconazole use ? | * invasive aspergillosis (DOC) |
| Voriconazole basics ? | * not affected by pH or food.... * hepatically eliminated |
| Voriconazole Side Effects ? | * Inhibits CYP3A4, Visual Changes, Neurotoxic, photosensitive rash, arrhytmias/QT prolongation |
| Caspofungin MOA ? | * Impairs cell wall production inhibits beta-(1,3)-D-glucan synthesis (cell wall component) weaken cell wall |
| Active against ? | * Active against Candida and aspergillus |
| When to use ? | * salvage therapy when Amp B or voriconazole has failed (or drug intolerance) |
Created by:
thamrick800
Popular Medical sets