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Intercellular Junct.

WVSOM Class of 2012 Intercellular Junctions

QuestionAnswer
Numerous different linking proteins tie the membranes of adjacent epithelial cells closely together around their apical perimeters. What are these called? tight junctions
tight junctions are also called what? zoneal occludens
what are bound by 2 adaptor proteins and cadherins? belt desmosome
multiple belt desmosomes anchor what? circumferential belt
Constriction of these microfilaments around the “necks” of these cells pull them into a bottleneck shape: circumferential belt
transmembrane complexes allowing diffusion of small molecules between cells are what? gap junctions
isolated “spot welds” joining two cells at their lateral surfaces; serve to tie together the cytoskeletons of multiple cells across a tissue. what are these structures? spot desmosomes
Complexes that anchor epithelial cells to the extracellular matrix of the basal lamina are what? hemidesmosomes
structures that anchor microfilament stress fibers to the basal surface of fibroblasts and cancer cells which have attached to the substratum are what structures? focal adhesions
what is a heterodimeric, transmembrane protein that binds a number of factors on both sides of the membrane? integrin
these junctions seal epithelial layers against diffusion by preventing molecules from passing between the cells: tight junctions
tight junctions also block passage of what? components of the plasma membrane (lipids, proteins) between the apical and basal regions of epithelial cells
gap junctions have how many polypeptides per junction? what shape are they? 12; hexagonal
what are some examples of molecules that pass through gap junctions? calcium for muscles, ions for nerves, camp for many tissues
belt desmosomes are also called what? adherens junctions
these link the microfilament cytoskeleton of one cell with that of another cell: belt desmosomes
which desmosome is most like a focal adhesion? belt desmosome
belt desmosomes anchor what fibers to the membrane? microfilaments
in belt desmosomes, the filaments are linked to the same adaptor proteins used in what other junction? focal adhesions
what are a family of calcium dependant transmembrane glycoproteins, often required for tissue specific cell-cell binding during development? cadherins
belt desmosomes are linked by what? cadherins
what are microfilament bundles attached to belt desmosomes, which encircle the apical perimeter of epithelial cells just below the tight junctions? circumferential belt
what is an autoimmune disorder that attacks one of the transmembrane linker proteins in spot desmosomes? pemphigus vulgaris
in hemidesmosomes, on the cytoplasmic side, intermediate filaments are bound to a pair of plaques consisting of what? adaptor proteins
adaptor proteins in hemidesmosomes are held to the plasma membrane by integrin, which is tied to what? laminin in the basal lamina
integrin is also used in focal adhesions where it links what to what? microfilaments to fibronectin
in focal adhesions, on the outer side of the membrane, integrin binds what to link the cytoskeleton with the extracellular matrix? fibronectin
Created by: mhassan
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