Busy. Please wait.
Log in with Clever

show password
Forgot Password?

Don't have an account?  Sign up 
Sign up using Clever

Username is available taken
show password

Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Didn't know it?
click below
Knew it?
click below
Don't Know
Remaining cards (0)
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

CNS Drugs Mechanisms

BS2014 Neuroscience Drug Targets in CNS and proposed mechanisms

Drug Category Function
Tricyclic Antidepressant - e.g. doxepine Inhibits re-uptake of NA or 5-HT
SSRIs (Antidepressants) - e.g. Prozac Selective serotonin re-uptake inhibitor
Irreversible MAOIs (Antidepressants) - e.g. phenelzine Inhibit metabolism of NA by monoamine oxidase inhibition (MAOI)
α-2 adrenoceptor antagonists (antidepressants) - e.g. mirtrazapine Enhance release of NA into synaptic cleft by inhibiting negative-feedback inhibition of NA release as triggered by binding of NA to pre-synatptic α-2 adrenoceptors (autoreceptors)
Manic symptoms (bipolar disorder); Lithium compounds - e.g. Lithium citrate Interfer with inositol recycling by inhibiting inositol monophosphate. Impacts a major (Gαq) pathway.
Stimulant; Amphetamine Sympathomimetic- competes for Uptake 1 and inhibits MOA; prevents NA removal from synaptic cleft.
Stimmulant; Cocaine Sympathomimetic - competes with NA for Uptake 1
Anti-epileptics (AED)- e.g. phenytoin Selectively block most active Na+ channels to inhibit the depolarisation.
Schizophrenia Antipsychotics - e.g. Haloperidol D2 (dopamine receptor) antagonist (atypical)
Schizophrenia Antipsychotic - e.g. Clozapine 5-HT 2A/2C (serotonin)receptor antagonist (atypical)
Schizophrenia Antipsychotic - e.g. mGluR 2/3 agonist (clinical trials) Inhibits glutamate release into synaptic cleft
Opioid Analgesics - e.g. morphine Opioid GPCR agonist = primarily μ, Gαi; βγ subunit activity on Na+ (deactivation- decreased influx), K+ (activation/ increased efflux) and Ca2+ (downregulated - decreased vesicular exocytosis conductance) - decreased neural excitability
Created by: Kingfisher
Popular Neuroscience sets




Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
restart all cards