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BS2014 - drugs

All the drugs from the BS2014 module at the University of Leicester

DrugDisorder/mechanism of action
Aspirin, paracetamol, ibuprofen, etc Pain - inhibit cox enzymes from converting arachidonic acid to prostaglandins
Diazepam Anxiety, insomnia - GABAa receptor agonist (sustained)
Alprazolam Anxiety, insomnia - GABAa receptor agonist (sustained)
Chlordiazepoxide Anxiety, insomnia - GABAa receptor agonist (sustained)
Clobazam Anxiety, insomnia - GABAa receptor agonist (sustained)
Lorazepam Anxiety, insomnia - GABAa receptor agonist (short acting)
Oxazepam Anxiety, insomnia - GABAa receptor agonist (short acting)
Buspirone Anxiety - serotonin receptor agonist
Propranolol Anxiety - beta-blocker
Oxprenolol Anxiety - beta-blocker
Phenytoin Epilepsy - use dependent block of sodium channels
Carbamazepine Epilepsy - use dependent block of sodium channels
Phenobarbital Epilepsy - GABAa receptor agonist
Primidone Epilepsy - GABAa receptor agonist
Vigabatrin Epilepsy - inhibits GABA aminotransferase, and hence GABA breakdown
Clomipramine Depression - inhibit noradrenaline and serotonin reuptake (tricyclic antidepressants)
Doxepin Depression - inhibit noradrenaline and serotonin reuptake (tricyclic antidepressants)
Trimipramine Depression - inhibit noradrenaline and serotonin reuptake (tricyclic antidepressants)
Imipramine Depression - inhibit noradrenaline and serotonin reuptake (tricyclic antidepressants)
Lofepramine Depression - inhibit noradrenaline and serotonin reuptake (tricyclic antidepressants)
Nortriptyline Depression - inhibit noradrenaline and serotonin reuptake (tricyclic antidepressants)
Citalopram Depression - selective serotonin re-uptake inhibitor (SSRI)
Escitalopram Depression - selective serotonin re-uptake inhibitor (SSRI)
Fluoxetine Depression - selective serotonin re-uptake inhibitor (SSRI)
Fluvoxamine Depression - selective serotonin re-uptake inhibitor (SSRI)
Paroxetine Depression - selective serotonin re-uptake inhibitor (SSRI)
Sertraline Depression - selective serotonin re-uptake inhibitor (SSRI)
Duloxetine Depression - serotonin - noradrenaline(norepinephrine) re-uptake inhibitor (SNRI)
Venlafaxine Depression - serotonin - noradrenaline(norepinephrine) re-uptake inhibitor (SNRI)
Phenelzine Depression - irreversible MAO inhibitor
Isocarboxazid Depression - irreversible MAO inhibitor
Tranylcypromine Depression - irreversible MAO inhibitor
Moclobemide Depression - reversible MAO inhibitor
Mirtrazapine Depression - alpha2-adrenoceptor antagonist
Lithium carbonate Manic depression/bipolar disorder - uncompetitively inhibits inositol monophosphatase
Lithium citrate Manic depression/bipolar disorder - uncompetitively inhibits inositol monophosphatase
Amphetamine Narcolepsy, ADHD - taken up by noradrenaline uptake 1, packaged into vesicles, inhibits MAO, acts weakly on adrenoceptors (also used recreationally)
Cocaine Mostly used recreationally, also used as a local anaesthetic - blocks re-uptake of noradrenaline, dopamine and serotonin
Chlorpromazine Psychosis - D2 receptor antagonist
Levomepromazine Psychosis - D2 receptor antagonist
Pericyazine Psychosis - D2 receptor antagonist
Pipotiazine Psychosis - D2 receptor antagonist
Fluphenazine Psychosis - D2 receptor antagonist
Perphenazine Psychosis - D2 receptor antagonist
Prochlorperazine Psychosis - D2 receptor antagonist
Trifluoperazine Psychosis - D2 receptor antagonist
Clozapine Psychosis - D2 receptor antagonist
Olanzapine Psychosis - D2 receptor antagonist
Phencyclidine Mostly recreational - NMDA receptor blocker (aka "angel dust")
Ketamine Mostly recreational - NMDA receptor blocker
Morphine Pain - agonist for opioid receptors, particularly mu receptor
Heroin Mostly recreational - opioid receptor agonist, particularly mu receptor
Naloxone Heroin overdose - high affinity competitive mu opioid receptor antagonist
Buprenorphine Heroin addiction - partial mu opioid receptor antagonist
L-DOPA Parkinson's disease - increases rate of dopamine synthesis by replacing DOPA
Carbidopa Parkinson's disease (used to optimise L-DOPA treatment) - inhibits peripheral DOPA decarboxylase
Benserazide Parkinson's disease (used to optimise L-DOPA treatment) - inhibits peripheral DOPA decarboxylase
Selegiline Parkinson's disease (used to optimise L-DOPA treatment) - inhibits MAO-B
Entacapone Parkinson's disease (used to optimise L-DOPA treatment) - inhibits COMT
Domperidone Parkinson's disease (used to optimise L-DOPA treatment) - blocks peripheral dopamine receptors
Bromocriptine Parkinson's disease - dopamine receptor agonist
Lisuride Parkinson's disease - dopamine receptor agonist
Pergolide Parkinson's disease - dopamine receptor agonist
Created by: 1384744449
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