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Hematology final
Question | Answer |
---|---|
What is erythrocytosis? | increase RBC count |
What is oligocythemia | decrease RBC count |
What are NV for adult RBC count? | men= 4.5-6 mill women= 4-5.5 mill |
What makes heme? | iron + protoporphyrin |
What makes globin? | RNA + amino acid |
What makes hemoglobin? | Iron heme and globin |
What is electrophoresis? | Seperates genetic types of hemoglobin |
What are normal values of hemoglobin? | Men= 15-17 g/dL Women 12-16 g/dL |
What diseases cause an increase in Hgb? | polycythemia vera and hydration |
What diseases cause a decrease in Hgb? | anemia, leukemia and bleeding |
What size drop of blood is used to make a differential blood smear? | Size of match head |
What is the composition of Wright's stain? | Alcohol colution, acid dye (eosin) and alkaline dye (ethylene) |
What is the function of a neutrophilic seg cell? | Phagocytosis of bacteria and small particles |
What is the function of eosinophilic segmented cells? | to limit effects of an allergic reaction |
What is the function of a monocyte? | phagocytosis of bacteria and large particles |
What is the function of a lymphocyte? | Produce antibodies and transplant rejection |
What are the three components of the cellular portion of the blood? | Erythrocytes, leukocytes, and thrombocytes |
What are the components of the fluid portion of the blood? | Water, protein, horomones, wastes, electrolytes |
How would blood settle in an anticoagulated tube from top to bottom? | Plasma, buffy coat then RBC |
What is leukocytosis? | Increase in WBC |
What causes leukocytosis? | Acute bacterial infections, pneumonia |
What is leukopenia? | Decrease in WBC |
What causes leukopenia? | Viral infections, influenza |
What are the normal values for an adult WBC? | 4000-11000 |
What is and example of a critical WBC count value? | >2 and more than 50 |
What tests make up a CBC? | RBC count WBC count Hemoglobin Hematocrit Differntial Estimation of platelet # RBC indices |
What are the 3 parts of the coagulation system? | Vascular, platelets, clotting factors/fibrin clot |
What are the three functions of platelets? | Addhere, aggrigatem platelet plug - release substances used in the formation of the fibrin clot - clot retraction |
What substance is necessary for the formation of the fibrin clot? and is also known as factor IV? | Calcium |
What is the meaning of thrombocytosis? | Increase of platelets |
What is thrombocytosis seen in? | Hemolytic anemias and hemorrage |
What is the meaning of thrombocytopenia? | Decrease platelet count |
What is thrombocytopenia seen in? | Aplastic anemia and pernicious anemia |
What factor is missing in Hemophilia A? | VIII (8) |
What factor is missing in Hemophila B? | IX (9) aka christmas factor |
What are two main causes of acquired clotting factor defciency? | Liver disease and vitamin K |
What does PT stand for? | Prothrombin Time |
What does the PT measure? | checks extrinsic system and coumadin measures time it takes to form a fibrin clot |
What does APTT stand for? | activated partial thromboplastin time |
What does the APTT measure? | Time it takes to form clot measures intrinsic and heparin |
What colored stopper tubes are used for coagulation studies? | Blue |
What is hematocrit? | percent volume occupied by the packed RBC |
How are Hb and Hct related? | Hgb X 3 = Hct +- 3 units |
When is the Hct increased? | polycythemia vera and dehydration |
When is the Hct decreased? | Anemia, leukemia, and excess fluid |
What kind of capillary tube is used to perform an Hct from tube blood? | plain/blue |
What kind of capillary tube is used to perform an Hct from a finger puncture? | red/ heparinized |
What three points are located to read an Hct results? | Bottom of packed cells, meniscus of plasma and top of packed cells below buffy |
What units are used with the Hct result? | women= 36-45% men= 42-52% |
What is the sedimentation rate? | Rate and speed at which RBC settle out of plasma |
What is the abbreviation for the sedimentation rate? | ESR |
What method is used to perform the ESR? | Westergram |