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M6 13-005

Exam 6: Meds that affect the GI (N/V)

Dimenhydrinate Dramamine
Dimenhydrinate uses Prevention & treatment of nausea, vomiting, dizziness, vertigo of motion sickness
Dimenhydrinate Adverse Reactions Dizziness, confusion, nervousness, restlessness, nausea, vomiting, diarrhea, blurred vision, palpitations
50-100 mg PO q4-6hr prn, max dose, 400mg/d, 50mg IM prn, 50mg IV Dimenhydrinate Doseage
Diphenhydramine Benadryl
Diphenhydramine uses Prevention & treatment of motion sickness, antihistamine
Diphenhydramine Adverse Reactions Dizziness, SEDATION, Epigastric Distress, faintness, allergic reactions, urinary frequency, thickening of bronchial secretions.
25-50mg PO q4-6hr, 10-50mg IM, IV Diphenhydramine Doseage
Dolastron Mesylate Anzemet
Dolastron Mesylate uses Prevention of chemo-induced N/V, postoperative N/V
Dolastron Mesylate Adverse Reactions Hypotension, hypertention, EKG changes, HA, dizziness, sedation, hunger, constipation
Before chemo: 100mg within 1hr., PO N/V: 100mg or 1.8mg/kg IV Dolastron Doseage
Granisetron Hydrochloride Kytril
Granisetron Hydrochloride Uses Prevention & Treatment of N/V due to antineoplastic drug therapy
Granisetron Hydrochloride Adverse Reaction HA, weakness, somnolence, diarrhea, constipation
10mcg/kg infused IV over 5min, 30min before chemo. or 1mg PO BID Granisetron Hydrochloride Doseage
Meclizine Antivert
Meclizine Uses Vertigo, prevention & treatment of N/V due to motion sickness, Menirere's Disease
Meclizine Adverse Reactions Drowsiness, restlessness, rash, uticaria, anorexia, hypotension, dry mouth, nose and throat
Vertigo: 25-100mg/d PO in divided doses; N/V: 25-50mg PO 1hr before travel and repeat 24h PRN Meclizine Doseages
metoclopramide Reglan
metoclopramide uses Prevention of N/V due to antineoplastic drug therapy, promote gastric emptying
metoclopramide adverse reactions Restlessness, drowsiness, fatigue, lassitude, dizziness, nausea, diarrhea
1-2mg/kg IV 15-30min before chemotherapy metoclopramide Dosage
Ondansetron Zofran
Ondansetron Uses Prevention of N/V due to antineoplastic drug therapy, postoperative N/V
Ondansetron Adverse Reactions Diarrhea, HA, fever, weakness, dry mouth, drowsiness, sedation
Chemo. 3 doses of 0.15mg.kg IV or 32mg PO 30min before chemo. post-op N/V; 4mg IV Ondansetron Dosage
Promethazine Hydrochloride Phenergan
Promethazine Hydrochloride Uses Tx of motion sickness
Promethazine Hydrochloride Adverse Reactions Dizziness, sedation, epigastric distress, faintness, allergic reactions, urinary frequency, thickening of bronchial secretions
Motion sickness: initial 25mg PO 1/2 before travel and repeat in 8-12hr; N/V 12.5-25mg PO, IM, IV Promethazine Hydrochloride Dosage
Transdermal Scopolamine Transderm-Scop
Transdermal Scopolamine Uses Prevention of N/V due to motion sickness
Transdermal Scopolamine Adverse Reactions Drowsiness, dry mouth, blurred vision
One system applied at least 4hr before effect is required, repeat in 3d if needed Transdermal Scopolamine Dosage
Trimethibenzamide Hydrochloride Tigan
Trimethibenzamide Hydrochloride Uses Control of N/V
Trimethibenzamide Hydrochloride Adverse Reactions Hypotension (IM use) Parkinson-like symptoms, blurred vision, drowsiness, dizziness
250mg PO TID, QID: 200mg IM, rectal suppository TID, QID Trimethibenzamide Hydrochloride Dosage
Prochlorperazine Hydrochloride Compazine
Prochlorperazine Hydrochloride Uses Control of N/V
Prochlorperazine Hydrochloride Adverse Reactions Drowsiness, hypotension, postural hypotension, bradycardia, dry mouth, nasal congestion
5-10mg PO TID, QID; 10-20mg IM, IV; 25mg rectal suppository BID; 10-15mg sustained release Prochlorperazine Hydrochloride Dosage
Created by: jtzuetrong