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Fungal RTI- Blue
Fungal infections of the respiratory tract- Blue 1/17/2013
| Question | Answer |
|---|---|
| Dimorphism | Exists in mycelial form in the soil and in yeast form in the body |
| Fugal infections are acquired by | Spores from the mycelial form |
| Why does the yeast form have a longer life span in the body? | It survives phagocytosis and therefor requires a specific cell-mediated response to be cleared |
| Histoplasmosis is common where? | Ohio-Mississippi Valley |
| Histoplasmosis growth is commonly associated with guano of | Birds, particularly starlings,chickens and bats |
| Histoplasmosis is acquired from | Inhalation of conidia which is converted to yeast in the lungs |
| Disease progression of histoplasmosis is associated with | Heavy infecting doses or immunodeficiency |
| Constant reinfection and resolution of histolplasmosis is often asymptomatic but presents with | Granulomas in the lungs (common in the midwest) |
| Symptoms of progressed histoplasmosis | Flu-like, patchy pneumonia that is chronic and relapsing |
| Classic pattern seen in histoplasmosis | Snowstorm or buckshot |
| In immunocompromised patients with histoplasmosis, dissemination may occur to | Spleen, Liver, Adrenals |
| Coccidiomycosis is commonly seen in regions of | Southwestern US (Desert) |
| Peak infection rates of coccidiomycosis are found after a | Desert rain |
| Coccidomycosis have a thick wall to protect from | Heat in the Desert |
| Coccidomycosis replicates by | Nuclear division which eventually walls off, leading to sacs of endospores |
| LIfe cycle of coccidomycosis | Arthrospores are inhaled from desert soil and are converted to yeast. Yeast goes through nuclear division to form spherules which contain endospores which infect |
| Coccidomycosis symptoms | Mild, flue-like illness, fever, cough, headache. Resolves in 2-6 weeks |
| Treatment for coccidomycosis | Azole drugs, Amphotericin B |
| Treatment for histoplasmosis | Azole drugs, Amphotericin B |
| North American Blastomycosis differs from Histoplasmosis in that it can also infect | Dogs |
| Balstomycosis patients may initially present with | Cutaneous lesions |
| Paracoccidiomycosis is limited to which areas | Central and South America, Tropical and Subtropical areas |
| Paracoccidiomycosis presents with | Cutaneous or mucocutaneous ulcers, especially in the oral and nasal cavities |