Save
Busy. Please wait.
Log in using Clever
or

show password
Forgot Password?

Don't have an account?  Sign up 
Sign up using Clever
or

Username is available taken
show password

why


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't know
Remaining cards (0)
Know
0:00
share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Lecture 26

Introduction to Disorders of Coagulation & Hemostasis

QuestionAnswer
What occurs during primary hemostasis? (1) Vascular phase: endothelial cell changes (2) Platelet phase: plt attach to injury site, formation of plt plug, support of coagulation reactions
What occurs during secondary hemostasis? The coagulation cascade
What is the physical response of blood vessels to injury? 1) vasocontriction via both neural stimulation and chemical vasocontrictors 2) elastic recoil of blood vessels
What is the anticoagulant effect of PGI2? Deters platelet aggregation
What is the anticoagulant effect of thrombomodulin? Binds thrombin and activates Protein C
What is the endothelial cell response to vessel injury? Subendothelial collagen and VWF binding sites exposed; Thrombomodulin and heparan is stripped away; PGI2 and tPA are no longer produced; tissue factor is exposed to Factor VII, initiating the coagulation cascade
What proteins are required for platelet binding to the site of vessel injury? 1) Von Willebrand Factor (VWF) 2) Platelet GP1b
(T or F) Platelet aggregation requires platelet activation and energy requiring process. True.
What platelet surface receptor is required for platelet aggregation? Glycoprotein IIbIIIa receptor
What platelet surface phospholipid is required for efficient enzymatic coagulation reactions? Phosphotidyl serine
What enzyme promotes reversal of Phosphotidyl choline (PC)/Phosphotidyl serine (PS) in the platelet bi-lipid membrane? Flipase
What is the importance of Calcium in coagulation? Catalyzes reactions by promoting attachment of enzymes and zymogens to phopholipid surface
What are the co-factors of the coagulation cascade? Factor VIII, V, III (Tissue Factor)
What are the enzymes of the coagulation cascade? Factors XIII, XII, XI, X, IX, VII, and II
What is the function of thrombin? 1)cleaves fibrinogento fibrin 2)activates plts 3)activates factor XI 4)activates factor XIII to XIIIa 5)activates Protein C when bound to thrombomodulin 6)at low levels-enhances FV and FVIII function 7)at high levels-destroys FV and FVIII
What laboratory study monitors the extrinsic pathway of the coagulation cascade? Protime (PT)
What laboratory study monitors the intrinsic pathway of the coagulation cascade? aPTT
What are the initiatiors of the coagulation cascade used in the lab aPTT assay? FXII, prekallikrein, and high molecular weight kininogen (HMWK)
(T or F) Deficiencies of FXII, Prekallikrein, and HMWK prolong the aPTT test but do not cause bleeding. True.
What coagulation factors require Vitamin K? Factor VII, IX, X, II
What is the importance of Vitamin K in coagulation? The enzymes Factor VII, IX, X, and II require gamma-carboxylation by Vit K dependent pathway. Carboxyl residues help enzymes bind to the surface.
What anticoagulant drug interferes with Vit K dependent pathways in the coagulation cascade? Coumadin (warfarin)
What are some common causes of Vitamin K deficiency? 1) poor intake 2) biliary disease 3) antibiotics interfering with Vit K metabolism in the gut
With coumadin therapy, which coagulation enzyme is inhibited first? Factor VII
What coagulation factors are monitored by PT? Measures Factor VII, V, X, II, and fibrinogen
For the lab PT assay, what initators are added to the patient's blood sample for clot formation? Thromboplastin (Tissue Factor and phospholipids) and calcium
What laboratory assay is used to monitor coumadin therapy? Prothrombin Time (PT)
What laboratory assay is used to monitor FVII deficiency? Prothrombin Time (PT)
A laboratory assay of clotting factors used to monitor the intrinsic pathway of coagulation. aPTT (activated partial thromboplastin time)
What laboratory study monitors heparin therapy? aPTT
Created by: UVAPATH4
 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards