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Path 14

Vascular Disease

What is Monckeberg Medial Sclerosis degenerative calcification of the media of large and medium sized muscular arteries usually in vessels of upper and lower extreimites of older people
What are the major risk factors for atherosclerosis advanced age, male sex, genetics, hyperlipidemia, hypertension, cigarette smoking, diabetes
Where are atherosclerotic lesions most likely to be located Medium to Large arteries
What is the name for a slightly elevated lesion in the intima consisting of smooth muscle cells and macrophages containing intracellular lipid? fatty streak
what is an atheroma (fibrofatty plaque) fibrous cap composed of smooth muscle cells, collagen, macrophages, and lymphocytes located in the intima beneath the endothelium with a core containing lipid filled macrophages adn smooth muscle cells (foam cells) and necrotic debris
What are the main complications of atherosclerosis Occlusion of the vessel, Narrowing of the vascular lumen, embolism, aneurysm formation
What is the most common site for atherosclerotic aneurysms distal aorta and common iliac arteries
What is a dissecting aneurysm An aneurysm in which blood enters the arterial wall through a tear in the intima and dissects along the length of the vessel
most common location for a dissecting aneurysm proximal aorta, starting with an intimal tear 1-2 cm above the aortic valve
where do syphilitic aneurysms tend to occur ascending aorta and arch
What is an aortic dissection a tear in the intimal layer of the aorta followed by formation and propagation of a asubintimal hematoma
A "double barreled aorta" refers to? Aortic dissection
Aortic dissection is more common in what patients? those with hypertension, connective tissue disorders, congenital aortic stenosis or bicuspid aortic valve and those with first degree relatives with history of thoracic dissections
what is cystic medial necrosis degenerative changes leading to breakdown of the collagen, elastin, and smooth muscle within the media and an increase in basophilic ground substance
Advanced cystic medial necrosis is the hallmark histologic change associated with dissection in those with ? syndrome Marfan's
What is type 1 Aortic Dissection involves the ascending aorta, aortic arch, and descending aorta
What is type II aortic dissection ascending aorta
What is type III aortic dissection confined to the descending aorta distal to the left subclavian artery
type IIIa refers to what type of dissection dissections that originate distal to the left subclavian artery but extends both proximally and distally, mostly above the diaphram
What is type IIIb aortic dissection dissections that originate distal to the left subclavian artery, extend only distally and may extend below the diaphragm
What are veins dilated due to incompetent valves called Varicose Veins
What are varicose veins of the rectum called Varicose Veins
Why are deep vein thrombosis considered a serious condition because of their propensity to embolize particularly to the pulmonary arteries
What is lymphangitis inflammation of the lymphatic vessels, particularly in the region of previous trauma to the skin
what is the pathogenic organism associated with lymphangitis B-hemolytic strep
What is a benign tumor of the blood vessels usually in the skin but may occur in internal organs Hemangioma
Where are capillary hemangiomas most frequently found in the skin, known as "birthmarks"
What are cavernous hemangiomas known as? port wine stains
What is a malignant tumor of the blood vesselsconsisting of neoplastic endothelial cells Angiosarcoma
What is angiosarcoma of the liver associated with? environmental carcinogens such as arsenic and vinyl chloride
What is a malignant tumor of endothelial cells that occurs frequently in patients with AIDS Kaposi Sarcoma
What virus is associated with Kaposi Sarcoma HHV8
Created by: UVAPATH1