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Path 8

Neoplasia IV pg 13-20 Templeton

Retinoblastoma is a tumor of? ocular neurons
when do ocular neurons stop replicating soon after the post natal period so retinoblastomas must arise during the time that the ocular neurons are still replicating
When cancer arises in hormonally-responsive tissues do they retain their hormone responsiveness yes they often retain their hormone responsiveness (this is why anti-hormone therapy can be used to treat hormonally responsive tumors)
how are patients with metastatic prostate cancer treated androgen deprivation therapy (orchiectomy and hormone antagonists)
Some cancers show increased secretion of proteinases such as Cathepsin and matrix metalloproteinases. What benefit do these proteinases provide allow cancer to spread locally and facilitate invation into and out of vascular structures during metastasis
how do cancers acquire the oxygen and nutrients that they need? they grow into existing vessels or create new ones with angiogenesis
what are some examples of angiogeneic cytokines VEGF, bFGF, and PD-ECGF (Vascular endothelial growth factor, Basic fibroblast growth factor, platelet derived endothelial cell growth factor)
what are telomeres found at the end of chromosomes made up of thousands of TTAGGG repeats that become shorter with each cell replication
what happens when telomeres become "too short" they are blocked from entering replication or undergo apoptosis
what does telomerase do? can elongate telomeres in "non-template directed" manner (normally expressed in germ cells and some stem cells)
Polycyclic aromatic hydrocarbons are found? in carbon fuel combustion and tobacco use
where are aflatoxins found in foods contaminated with aspergillus
what effect does high energy radiation have on DNA? causes double strand DNA breaks
High energy radiation increases the risk of all cancers but especially which ones? lymphoma/leukemia, sarcomas, and thyroid neoplasms
what is required for "fixation" of mutagenic effects? Replication
Do lymphomas/sarcomas or carcinomas tend to be aneuploid with complex, non-uniform genomic changes Carcinomas
Do Lymphomas/Sarcomas or carcinomas tend to have specific translocations Lymphomas and sarcomas
Created by: UVAPATH1



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