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Answer:

Across
1Short feed back loop - anterior pituitary inhibits hypothalamus e.g. GH and PRL Long feedback loop - endocrine gland inhibits both anterior pituitary and _____ e.g. cortisol, IGF and testosterone
3The pituitary gland sits at the base of the skull in a _____ of the sphenoid bone called the sella turcica This is a bony cavity in which the pituitary sits Relatively protected from trauma except the stalk Tumours cannot expand within the fossa
4Due to excess GH secretion after epiphyseal plates have fused Enlargement of hands and feet Coarsening of facial features - largening of nose Weight gain
5Inactivating mutation in GHRH receptor - dwarfism No response to GHRH due to a single AA change in the GPCR Gigantism due to excess GH secretion Short stature if lack GH Only if occurs before epiphyseal plate fusion
Down
2Metabolites, sleep, stress and exercise trigger hypothalamus to secrete growth hormone releasing hormone Anterior pituitary somatotroph cells release growth hormone Short feedback loop GH acts directly + via liver IGFs to induce bone and _____ growth
4A polypeptide hormone from POMC precursor - secreted by corticotroph cells GPCR coupled to cAMP Stimulates secretion of cortisol from adrenal cortex in stress Stimulates growth of adrenal cortex
 
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