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Answer:

Across
1A disorder characterized by rapid _____ iron buildup in the liver, heart and pancreas of a neonate resulting in stillbirth or death wihtin a few days of birth.
4What is the _____ of all iron bound to tranferrin in the body?
5A disorder associated with hemojuvelin mutation that causes iron accumulation at an early age (age 15-30yrs). _____ clinical findings include diabetes, impotence, amenorrhea, infertility, and cardiac arrhythmias and heart failure.
7Inflammatory and infectious disorders release factors suprressing erythropoiesis. IL-1 causes the release of lactoferrin from neutrophils. _____ binds Fe more avidly than transferrin, shunting Fe to macrophages rather than to erythroid precursors.
Down
2Pathogenesis of sideroblastic _____
3What is the difference _____ IRP-1 and IRP-2 (iron regulatory proteins)?
6(T or F) Ferritin levels in circulation is generally proportional to the size of the body reticuloendothelial cell iron store.
 
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