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acidsbasesbuffers

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Question
Answer
Define pH.   pH is the negative log of the concentration of hydrogen ions (such concentration expressed in moles per liter [mol/L]) in a solution. This determines the acidity of the solution.  
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Given any hydrogen ion concentration, determine the pH and vice versa   pH = -log[H+],  
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The normal [H+] of blood is 40nM. Calculate the pH.   pH = -log (H+)= -log 40 x 10-9  
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Recognize the acids produced by the body during metabolism and be able to state the predominant form at pH = 7.4 (ic or ate, ammonium or ammonia).   1.)H2SO4 Sulfuric Acid 2.)HNO3 Nitric Acid 3.)HCl Hydrochloric Acid  
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To find if bicarbonate or carbonic acid predominates at pH=7.4, use the Henderson-Hasselbalch equation. Solve for the ratio of Bicarbonate to Carbonic Acid (pKa = 6.1):   7.4 = 6.1 + log ([Bicarbonate]/[Carbonic Acid])  
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Equation for its dissociation of a weak acid:   HA = H+ + A- [HA]= weak acid concentration, [A-]= conjugate base concentration, [H+]= proton concentration  
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Be able to define the Ka for the acid.   Ka=[H+][A-]/[HA] Ka: dissociation constant, ::[HA]= weak acid concentration, [A-]= conjugate base concentration, [H+]= proton concentration  
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Relationship between pKa and Ka   pKa=-log(Ka)  
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Bicarbonate Buffer System equation:   CO2 + H2O <---> H2CO3 <---> HCO3- + H+  
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The partial pressure of CO2 can be roughly converted to the concentration of Carbonic Acid in the bloodstream by doing what?   multiplying [PaCO2] by .03. Example: (40 mm Hg CO2) X .03 = (1.2 milli moles Carbonic Acid) in the blood stream. (Reference range for CO2 in blood is 37-43 mm Hg).  
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Henderson-Hasselbalch Equation for bicarbonate buffer system   pH = 6.1 + log([HCO3-]/[H2CO3])  
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Draw the dissociation of ammonium ion. If the pKa =9.3, what form is found at pH = 7?   pH = pKa + log [salt]/[acid] pH = pKa + log[NH3]/[NH4+]  
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The equation for the dissociation of ammonium ion   NH4+ <--> NH3 + H+  
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If pH > pKa, what predominates?   salt is predominant  
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if pH < pKa, what predominates?   acid is predominant  
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Created by: carolanimal
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