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Reg of Enzyme Activi
WVSOM Class of 2012 Regulation of Enzyme Activity
| Question | Answer |
|---|---|
| 3 methods for enzyme regulation? | allosteric, covalent modification, and transcriptional regulation |
| what groups disrupt conformational change and are important in covalent modification? | kinases and phosphatases |
| when pk is phosphorylated, is it active or not? | inactive |
| what happens to the insulin receptor and glycogen phosphorylase when they are phosphorylated? | they become active |
| what is reponsible for the fight or flight reflex? | glycogen phosphorylase |
| protein kinase A is what kind or regulator? | covalent modification |
| glycosylation does what to protein groups? | adds a carbohydrate |
| to add a protein to a membrane, what should be added? | a fatty acid |
| acetylation is important to what regulation? | histone |
| amino acid modification examples include: | glycosylation, fatty acid prenylation |
| what do matrix metalloproteases do? | enzymes that degrade extracellular matrix proteins |
| what is a t.i.m.p.? | tissue inhibitor of metalloproteases |
| what is a zymogen? | inactive protein |
| what can activate a zymogen? | proteolysis |
| this process is used in nuclear proteins and is simliar to ubiquitinization? | sumoylation |
| in transcriptional control, what reactions can be controlled? | transcription, translation, or degradation |
| in eukaryotic cells, what can regulate enzymes? | feedback and feedforward; isoenzymes |
| is the rate regulating step reversible? | no |
| feedforward has an increased supply of what? name an example: | substrate; glycogen/insulin system |
| isoenzymes have similar actions; are their structures the same or different? | different |
| what are examples of isoenzymes? | glucokinase, hexokinase |
| what do multienzymes do? give an example: | transfer substrate to adjacent enzyme; microsomal ethanol oxidizing system (MEOS) |
| what are some examples of regulation via proteolysis? | coagulation factors and chymotrypsin |
| feedback regulation is most often an example of what kind of regulation? | allosteric |
| give an example of compartmentalization: | TCA |
Created by:
mhassan
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