click below
click below
Normal Size Small Size show me how
une ch 4
acidsbasesbuffers
Question | Answer |
---|---|
Define pH. | pH is the negative log of the concentration of hydrogen ions (such concentration expressed in moles per liter [mol/L]) in a solution. This determines the acidity of the solution. |
Given any hydrogen ion concentration, determine the pH and vice versa | pH = -log[H+], |
The normal [H+] of blood is 40nM. Calculate the pH. | pH = -log (H+)= -log 40 x 10-9 |
Recognize the acids produced by the body during metabolism and be able to state the predominant form at pH = 7.4 (ic or ate, ammonium or ammonia). | 1.)H2SO4 Sulfuric Acid 2.)HNO3 Nitric Acid 3.)HCl Hydrochloric Acid |
To find if bicarbonate or carbonic acid predominates at pH=7.4, use the Henderson-Hasselbalch equation. Solve for the ratio of Bicarbonate to Carbonic Acid (pKa = 6.1): | 7.4 = 6.1 + log ([Bicarbonate]/[Carbonic Acid]) |
Equation for its dissociation of a weak acid: | HA = H+ + A- [HA]= weak acid concentration, [A-]= conjugate base concentration, [H+]= proton concentration |
Be able to define the Ka for the acid. | Ka=[H+][A-]/[HA] Ka: dissociation constant, ::[HA]= weak acid concentration, [A-]= conjugate base concentration, [H+]= proton concentration |
Relationship between pKa and Ka | pKa=-log(Ka) |
Bicarbonate Buffer System equation: | CO2 + H2O <---> H2CO3 <---> HCO3- + H+ |
The partial pressure of CO2 can be roughly converted to the concentration of Carbonic Acid in the bloodstream by doing what? | multiplying [PaCO2] by .03. Example: (40 mm Hg CO2) X .03 = (1.2 milli moles Carbonic Acid) in the blood stream. (Reference range for CO2 in blood is 37-43 mm Hg). |
Henderson-Hasselbalch Equation for bicarbonate buffer system | pH = 6.1 + log([HCO3-]/[H2CO3]) |
Draw the dissociation of ammonium ion. If the pKa =9.3, what form is found at pH = 7? | pH = pKa + log [salt]/[acid] pH = pKa + log[NH3]/[NH4+] |
The equation for the dissociation of ammonium ion | NH4+ <--> NH3 + H+ |
If pH > pKa, what predominates? | salt is predominant |
if pH < pKa, what predominates? | acid is predominant |