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Digestive System

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Answer
gastrointestinal (GI) tract (alimentary canal)   mouth, most of pharynx, esophagus, stomach, small intestine, and large intestine  
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accessory digestive organs   teeth, tongue, salivary glands, liver, gallbladder, and pancreas  
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digestive process   ingestion, secretion, mixing and propulsion, digestion, absorption, and defecation  
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secretion   water, acid, buffers, and enzymes into lumen from GI tract cells  
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mixing and propulsion   alternating contractions and relaxations of smooth muscle in the walls of the GI tract, known as motility  
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digestion   mechanical digestion churns food; chemical digestion – hydrolysis  
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components of the wall of GI tract   mucosa, submucosa, muscularis, and serosa  
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mucosa's 3 layers   epithelium, lamina propria, and muscularis mucosae  
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lamina propria   connective tissue with blood and lymphatic vessels and mucosa-associated lymphatic tissue (MALT) that contain immune system cells  
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muscularis mucosae   thin layer of smooth muscle making folds to increase surface area  
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submucosa   connective tissue binding mucosa to muscularis; contains many blood and lymphatic vessels; submucosal plexus (neurons)  
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muscularis   voluntary skeletal muscle (mouth, pharynx, esohpagus, and anal sphincter) and involuntary; arranged in circular fibers and outer longitudinal fibers; myenteric plexus  
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enteric nervous system (ENS)   extends from esophagus to anus; myenteric plexus and submucosal plexus; motor neurons, interneurons, and sensory neurons  
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myenteric plexus (plexus of Auerbach)   located between circular and longitudinal smooth muscle layers; controls GI tract motility  
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submucosal plexus (plexus of Meissner)   located within the submucosa; controls secretions  
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ANS influence   parasympathetic stimulation increases secretions and motility by stimulating the ENS; sympathetic stimulation inhibits ENS  
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peritoneum   largest serous membrane in the body; parietal peritoneum, peritoneal cavity, and visceral peritoneum  
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ascites   accumulation of liters of fluid in the peritoneal cavity  
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parietal peritoneum   lines the wall of the abdominopelvic cavity  
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visceral peritoneum   covers some of the organs in the cavity  
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retroperitoneal   kidneys, ascending and descending colons, duodenum, and pancreas (located behind the peritoneum)  
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major peritoneal folds (5)   greater omentum, falciform ligament, lesser omentum, mesentery, and mesocolon  
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greater omentum   the largest peritoneal fold that drapes over the transverse colon and small intestine like a “fatty apron”  
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falciform ligament   attaches the liver to the anterior abdominal wall and diaphragm  
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lesser omentum   suspends the stomach and duodenum from the liver  
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mesentery   binds the jejunum and ileum of the small intestine to the posterior abdominal wall  
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mesocolon   binds the transverse colon and sigmoid colon to the posterior abdominal wall  
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structure of the mouth   cheeks, hard and soft palates, and tongue  
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uvula   a conical muscular process hanging from the soft palate; drawn superiorly during swallowing to prevent food from entering the nasal cavity  
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function of salivary glands   when food enters the mouth, secretion increases to lubricate, dissolve, and begins chemical digestion  
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3 pairs of salivary glands   parotid, submandibular, and sublingual  
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parotid glands   located between the skin and masseter muscle; secrete saliva via a parotid duct  
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submandibular glands   found in the floor of the mouth; submandibular ducts  
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sublingual glands   Found beneath the tongue; lesser sublingual ducts  
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saliva   99.5% water and 0.5% solutes;ions, dissolved gases, urea, uric acid, mucus, IgA, lysozyme, and salivary amylase  
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urea and uric acid in saliva   helps remove waste molecules  
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IgA in saliva   prevents attachment of microbes  
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tongue structure   skeletal muscle covered with mucous membrane; attached to the hyoid bone; extrinsic muscles (hyoglossus, genioglossus, and styloglossus); intrinsic muscles; lingual frenulum (fold of mucous membrane on the bottom of the tongue)  
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tongue function   maneuvers food for chewing, shapes mass, and forces food back for swallowing  
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lingual glands   secrete salivary lipase (fats and oils)  
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ankyloglossia   abnormally short or rigid lingual frenulum resulting in an impairment of speech  
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major regions of a tooth (3)   crown, root, and neck  
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layers of a tooth (5)   enamel, dentin, cementum, pulp, and root canals  
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dentitions   sets of teeth  
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deciduous dentitions   primary teeth, milk teeth, or baby teeth; 20 teeth (no molars)  
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permanent dentitions   deciduous teeth replaced somewhere between the ages of 6-12; 32 teeth  
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pharynx   food passes into the oropharynx and laryngopharynx; the muscular contractions in those areas help propel food into the esophagus to the stomach  
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histology of the esophagus   mucosa, submucosa, muscularis, sphincters, and adventitia (attaches to the surroundings)  
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function of the esophagus   secretes mucus and transports food  
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upper esophageal sphincter (UES)   regulates movement into the esophagus  
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lower esophageal sphincter (LES)   regulates movement into the stomach  
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deglutition   swallowing; involving mouth, pharynx, and esophagus  
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3 stages of deglutition   voluntary, pharyngeal, and esophageal  
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peristalsis   progression of coordinated contractions and relaxations to push a bolus forward; occurs in the esophageal stage  
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pharyngeal stage   when bolus enters the oropharynx it sends impulses to the deglutition center in the medulla; returning impulse tells the uvula to ascend and the epiglottis to close  
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four main regions of the stomach   cardia, fundus, body, and pylorus  
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pylorus (2)   pyloric antrum, connects to the body of the stomach; pyloric canal, connects into the duodenum  
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histology of the stomach   mucosa, submucosa, muscularis, and serosa  
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mucosa of the stomach   gastric glands open into gastric pits; mucous neck cells, parietal cells, chief cells, and G-cells  
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mucous neck cells   secrete mucus  
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parietal cells   produce intrinsic factor (for absorption of B12) and hydrochloric acid  
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chief cells   secrete pepsinogen and gastric lipase  
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G-cells   endocrine cell that secrete gastrin  
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gastrin   stimulates gastric activity  
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muscularis of the stomach   has an additional 3rd inner oblique layer  
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serosa of the stomach   part of the visceral peritoneum  
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rugae   folds of the stomach when it is empty  
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mechanical digestion in the stomach   mixing waves (produces chyme) and gastric emptying (forces 3 mL of chyme into the duodenum)  
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chemical digestion in the stomach   salivary amylase (digestion of starch continues until inactivated by gastric juice), lingual lipase (gastric juice activates it), and HCl (secreted by parietal cells; the proton pumps powered by H+/K+ ATPases)  
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pepsin   secreted by chief cells in its inactive form pepsinogen, becomes active when in contact with HCl; helps breakdown proteins  
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why is pepsin secreted in an inactive form?   it would breakdown the chief cells that produce it; the stomach is protected by a 1-3mm thick alkaline mucus  
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gastric lipase   breaks triglycerides into fatty acids and monoglycerides  
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location of the pancreas   retroperitoneal, lies posterior to the greater curvature of the stomach  
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anatomy of the pancreas   head, body, tail, and two ducts  
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pancreatic duct (duct of Wirsung)   (larger duct) joins the common bile duct from the liver and gallbladder and enters the duodenum at the hepatopancreatic ampulla  
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sphincter of hepatopancreatic ampulla (sphincter of Oddi)   regulates pancreatic juice and bile into the small intestine  
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accessory duct (duct of Santorini)   leads from the pancreas into the duodenum, just above the hepatopancreatic ampulla  
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pancreatic acini   99% of the epithelial clusters; constitute the exocrine portion; secrete a mix of fluid and digestive enzymes (pancreatic juice)  
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pancreatic islets (islets of Langerhans)   1% endocrine portion; secrete glucagon, insulin,somatostatin, and pancreatic polypeptide  
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pancreatic juice (5)   neutral pH, somewhat alkaline; sodium bicarbonate, pancreatic amylase, proteolytic enzymes, pancreatic lipase, and deoxy/ribonuclease  
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sodium bicarbonate in pancreatic juice   buffers chyme, stops pepsin from the stomach, and creates the proper pH for enzymes in the small intestine  
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proteolytic enzymes   trypsin activates enzymes  
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liver anatomy   two lobes joined by the falciform ligament, inferior quadrate lobe, and posterior caudate lobe; coronary ligament suspends the liver from the diaphragm  
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ligamentum teres (round ligament)   remnant of the umbilical vein of the fetus  
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histology of the liver   hepatocytes, bile canaliculi, hepatic sinusoids, and Kupffer cells  
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hepatocytes   major functional cells of the liver; secretes bile  
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bile canaliculi   ducts between hepatocytes that collect bile; exit liver as common hepatic duct and joins the cystic duct from the gallbladder to form common bile duct  
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hepatic sinusoids   receives oxygenated blood form hepatic artery and deoxygenated nutrient-rich blood from hepatic portal vein  
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stellate reticuloendothelial (Kupffer) cells   destroy worn-out RBCs, WBCs, and bacteria from the GI tract  
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portal triad   bile duct, hepatic artery, and hepatic vein  
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bile properties   yellow, brownish liquid; pH 7.6-7.8; water bile salts, cholesterol, lecithin, bile pigments and ions  
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bile function   partial excretory product and partial digestive secretion; bile salts play a role in emulsification and providing a large surface area for pancreatic lipase  
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emulsification   breakdown of a large lipid globule into smaller lipid globules  
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liver functions   bile synthesis and secretion; carbohydrate metabolism; lipid metabolism; protein metabolism; processing drugs and hormones; excretion of bilirubin; storage for vitamins; phagocytosis; and activation of Vit-D  
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small intestine regions (3)   duodenum, jejunum, and ileum  
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small intestine histology   mucosa, submucosa, muscularis, and serosa  
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small intestine mucosa   absorptive cells, goblet cells (mucus), intestinal glands (intestinal juice), paneth cells (lysozyme), enteroendocrine cells, and MALT  
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small intestine serosa   completely surrounds the organ except for a major part of the duodenum  
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circular folds (plicae circulares)   ridges of mucosa and submucosa cause chyme to spiral (increased surface area for absorption)  
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villi   finger-like projections of the mucosa; contain an arteriole, venule, blood capillary and lacteal  
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microvilli   projections of apical (free) membrane of absorptive cells; brush border with brush border enzymes  
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intestinal juice   water and mucus; slightly alkaline; 1-2L; provides liquid medium aiding in absorption  
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brush border enzymes   produced by absorptive cells and inserted into plasma membrane by microvilli; carbs, proteins, and nucleic acids  
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mechanical digestion in the small intestine   controlled by myenteric plexus; segmentations, mixing contractions to bring chyme in contact with mucosa; migrating motility complexes (MMC)  
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carbohydrate digestion in the small intestine   pancreatic amylase, α-dextrinase, sucrase, lactase, and maltase break them to monosaccharides which can be absorbed  
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protein digestion in the small intestine   trypsin, chymotrypsin, carboxypeptidase, and elastase from pancreas; completed by aminopeptidase and dipeptidase in brush border  
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lipid digestion in the small intestine   pancreatic lipase and emulsification by bile salts  
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nucleic acid digestion in the small intestine   ribonuclease and deoxyribonuclease in pancreatic juice; nucleosidases and phosphatases in brush border.  
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absorption in the small intestine   occurs by facilitated diffusion into blood (monosaccharides, amino acids, dipeptides, and tripeptides); lipids absorbed by simple diffusion  
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micelles   formed by bile salts and ferry chains of fatty acids and monoglycerides for absorption  
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chylomicrons   formed within a cell it is recreated from triglycerides  
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lacteals   used to transport lipids into blood with a chylomicron protein coat  
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electrolyte absorption   sodium ions reclaimed by active transport along with some other ions  
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vitamin absorption   fat-soluble absorbed by simple diffusion  
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water absorption   9.3L ingested, 7.0L in GI secretions; occur by osmosis  
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daily volume   9.3L ingested/secreted, 0.1L excreted,; total absorbed 9.2L  
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large intestine regions (5)   cecum, appendix, colon, rectum, and anal canal  
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ileocecal sphincter   regulates passage of chyme between the small intestine and large intestine  
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colon divisions (4)   ascending, transverse, descending, and sigmoid  
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internal anal sphincter   smooth muscle  
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external anal sphincter   skeletal muscle  
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histology of large intestine   mucosa, submucosa, muscularis, and serosa  
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large intestine mucosa   no circular folds or villi; does have microvilli on absorptive cells  
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large intestine muscularis   longitudinal muscle modified to form teniae coli also forms haustra (pouches, segments seen)  
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mechanical digestion by the large intestine   haustral churning, peristalsis, mass peristalsis (pushes contents toward the rectum)  
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chemical digestion by the large intestine   final stage by bacterial action; ferment carbs; produces some vitamins B and K; mucus but no enzymes  
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phases of digestion (3)   cephalic phase, gastric phase,and intestinal phase  
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cephalic phase   smell, sight, thought or initial taste of food activates neural centers; prepares mouth and stomach for food to be eaten  
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gastric phase   neural regulation by stretch receptors and chemorecptors; hormonal mechanisms (gastrin from G-cells); promotes gastric secretion and motility  
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intestinal phase   begins when food enters small intesting; slows exit of chyme from the stomach  
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cholecystokinin (CCK)   stimulates flow of bile and pancreatic juice; from CCK cells in the small intestinal crypts in response to chyme containing amino acids  
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secretin   stimulates flow of pancreatic juice that is rich in bicarbonate (HCO3-) ions to buffer the acidic chyme; produced by S cells of the small intestinal crypts  
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