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Trilaminar Stage

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Question
Answer
Hensen's node   Serves as organizer, secreting growth factors that induce tissue type differentiation and embryogenic patterning  
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Primitive pit   Pore in center of Hensen's node  
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Primitive streak (day 15 - week 4)   Faint white trace at caudal end of embryonic disc, formed by movement of cells at onset of mesoderm formation and providing 1st evidence of embryonic axis  
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Primitive ridges   Ridge that bounds the primitive groove in early stages of embryonic development  
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Primitive groove   Lengthwise median furrow in primitive streak of the embryo  
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Situs inversus   Developmental defect when viscera in abnormal left-right orientations; probably results from defective GF genes secreted from embryonic organizer (i.e. Hensen's node)  
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Partial situs inversus   Some organs are in opposite orientations; can be fatal  
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Total situs inversus   All organs are transposed; little to no clinical consequences  
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Primitive streak expansion, regression   Begins at caudal end of germ disc; elongates towards cranial end (until day 18); extends across ~2/3 length of germ disc; streak regresses, completely disappearing by 4th week  
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Grastrulation   First movement of embryonic cell populations, serving to compartmentalize embryo into 3 germ layers - ectoderm, endoderm, mesoderm  
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How is gastrulation accomplished?   With the primitive streak  
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What cells invaginate to form the primitive groove along the caudal medial line?   Epiblastic cells  
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Endoderm (intraembryonic endoderm)   Cells that have wedged into hypoblast (from the invagination and separation of cells form the epiblast); eventually, endoderm completely replaces hypoblast by pushing it out of germ disc and into yolk sac  
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Mesoderm   Invaginating cells (from the epiblast) that do not wedge into the hypoblast  
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Ectoderm   Epiblastic cells that do not pass through the primitive streak  
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From what are all three germ layers derived?   Epiblast  
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What gives the germ disc a pear shape perimeter?   The cells that migrate into the space between the epiblast and hypoblast spread in lateral and cranial directions  
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What plate do the cells that move in the cranial direction form?   Cardiogenic (heart forming) plate  
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What else can the cranial migrating cells generate?   The notochord  
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Which cells reach the cranial extremities first?   The first cells to pass through the streak; caudual mesoderm and endoderm = younger, differentiation slightly delayed; embryos tend to develop from cranial end towards caudal  
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Sacrococcygeal teratomas   Develop when primitive streak fails to regress; most common newborn tumors; derived from pluripotent cells; consist of misture of different cell types; tumors can usually be surgically removed  
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Caudal dysgenesis   Underdevelopment of caudal features due to insufficient mesoderm in caudal-most region of embryo  
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Symptoms/abnormalities of caudal dysgenesis   Hypoplasia, fusion of lower limbs, vertebral abnormalities, renal agenesis, imperforate anus, anomalies of genital organs  
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Sirenomelia   Extreme condition of caudal dysgenesis; legs fused to produce mermaid-like fetus; common teratogenic factor = maternal diabetes  
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Notochord   Hollow, cartilaginous rod that extends through midline; phylum named after it (Chordata)  
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Notochord's role in vertebrates   Organizer  
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What is the notochord derived from?   Hensen's node  
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What differentiation does the notochord control?   Neural tube, somites  
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What happens to the notochord after it has served its purpose?   Majority of it degenerates by apoptosis; some notochordal derived cells persist in adult as nuclei pulposus of intervertebral discs  
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Formation of notochord   Epitblast cells that invaginated thru primitive pit remain contiguous, extend in cranial direction to form hollow tube (notochordal process), lumen of tube = notochordal canal  
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What region prevents the continuation of the notochordal process?   Prechordal plate (progenitor of mouth); regions contains hypoblast & epiblast celss that block further progression of process; at this point, primitive streak regression commences; occurs around day 18  
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What does the notochord fuse with?   Underlining endoderm  
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What results from the fusion of the notochord with the underlining endoderm?   Opening to yolk sac; transitory channel (via primitive pit) connects amniotic cavity & yolk sac  
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What is the connection between the amniotic cavity & yolk sac called?   Neurenteric canal  
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The tubular process that has been flattened is called ...   Notochordal plate  
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The notochordal plate folds (reforming a tube), starting at the cranial end & progressing towards the caudal end   Notochord  
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What happens when the notochord detaches from the yolk sac endoderm?   The neurenteric canal closes  
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