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Cards that cover all 25 lectures

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
What is a major source of energy for the body?   show
🗑
show Starch  
🗑
Simple sugars that contain four to eight carbons and only one aldehyde or ketone group   show
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What type of sugars can give up electrons?   show
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What are examples of monosaccharides?   show
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Formed by the interaction of two monosaccharides with the loss of a water molecule   show
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show Disaccharides  
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show maltose lactose and sucrose  
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show Polysaccharides  
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show Starch and Glycogen  
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What breaks down ingested starches into disaccharides?   show
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Monosaccharides are broken down by _______   show
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show Monosaccharides  
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Where is glycogen stored in the body?   show
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show Glycogenesis  
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show Glycogenolysis  
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Catabolism of glucose to pyruvate or lactate for adenosine triphosphate (ATP) production. (Embden-Meyerhof pathway and Krebs' cycle)   show
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show Insulin  
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show Glucagon  
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show Epinephrine  
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show Growth Hormone and Adrenocorticotropic hormone  
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show Glucocorticoids  
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show Thyroid hormones  
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What effect does insulin have on glucose levels?   show
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What effect does glucagon have on glucose levels?   show
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What effect does epinephrine have on glucose levels?   show
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show growth hormone and adrenocorticotropic hormone increase glucose levels  
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What effect does glucocorticoids have on glucose levels?   show
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show thyroid hormone will increase blood glucose levels  
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This disorder occurs when fasting blood sugar level rises higher than 110 mg/dl due to a pathological disorder, such as diabetes or liver failure   show
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show Hypoglycemia  
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show hormone deficiency, drug reaction, insulin excess, or a genetic disorder  
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Sugar in the urine   show
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show Glycosuria  
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Acute state with hyperglycemia and ketosis. Caused by an autoimmune destruction of the pancreatic beta cells.   show
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Glucose is oxidized to gluconic acid and hydrogen peroxide to eventually form a colored product. Falsely low results are caused by high serum levels of uric acid, bilirubin, or ascorbic acid   show
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Glucose becomes phosphorylated and dehydrogenated to eventually form NADPH   show
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show Glucose Tolerance Test  
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This test is used to evaluate diabetes. A fasting blood specimen and a specimen taken 2 hours after breakfast are collected.   show
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Organic compounds that contain both an amino group and a carboxyl group.   show
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Proteins are composed of what?   show
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How much essential amino acids be supplied?   show
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What are the essential amino acids?   show
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show Ketoacids  
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Glycogenic to generate glucose precursors or Ketogenic to generate ketone bodies:   show
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Inherited disorder causing lack of phenylalanine to tyrosine, which results in the formation of phenylpyruvate   show
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show Maple Syrup urine disease (MSUD)  
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show Homocysteinuria  
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Responsible for osmotic pressure of plasma and serves as a transport protein.   show
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Immunoglobulins are _____ in water   show
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show In the liver (serum proteins) or by B-cells (immunoglobulins)  
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Where does protein catabolism take place?   show
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Peptide chains that hydrolyze to amino acids   show
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Composed of protein and a nonprotein substance, such as lipid, carbohydrate, or metals   show
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What are the functions of protein?   show
🗑
show Enzymes  
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show Composed of a specific amino acid sequence (primary), which results in a stearic arrangement (secondary) that becomes folded (tertiary)  
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show a substrate and an allosteric site  
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Catalyze an oxidation-reduction reaction. Examples include lactate dehydrogenase and G6PD   show
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show Transferases  
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Expresses the relationship between the velocity of any enzymatic reaction and the substrate concentration.   show
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show Km  
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show V = Vmax [S] / ( Km + [S] )  
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show First-order kinetics  
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show Zero-order kinetics  
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show Enzyme Concentration  
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Each enzyme operates maximally at a specific ____   show
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show Increased temperature increases the rate by increasing the movement of molecules  
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How does the cofactor concentration affect the velocity of an enzymatic reaction?   show
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Binds to the active site of the enzyme, causing Km to increase   show
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Binds at a place other than the active site, causing Vmax to decrease   show
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Binds to the ES complex; both Vmax and Km decrease   show
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How can enzyme activity be measured?   show
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show Endpoint measurements  
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show Kinetic measurements  
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show International Unit of enzyme Activity  
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Hydrolyzes phosphate esters, but the function of this enzyme is relatively unknown   show
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show Liver, bone, intestines, kidney, and placenta  
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show Decreased values  
🗑
How can a hemolyzed sample affect an ALP value?   show
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What is the diagnostic significance of ALP?   show
🗑
show Bone, liver, intestinal, and placental fractions  
🗑
Transfers an amino group between aspartate and keto acids. Vitamin B6 is the coenzyme in this reaction   show
🗑
show cardiac tissue, liver, skeletal muscles, and RBCs  
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Catalyzes the transfer of an amino group from alanine to alpha-ketoglutarate with the formation of glutamate and pyruvate.   show
🗑
show Liver, some in the heart, skeletal muscle, and RBCs  
🗑
Clinical significance of ALT   show
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show Creatine Kinase  
🗑
CK is involved in the storage of what?   show
🗑
Where is CK localized?   show
🗑
show Elevation in muscle disorders. CK and one of its isoenzymes is a sensitive indicator of acute myocardial infarction and muscular distrophy.  
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Catalyzes the interconversion of lactic and pyruvic acids. It is a hydrogen-transfer enzyme that uses the coenzyme NAD.   show
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Where is LD distrubuted?   show
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show Diagnosis of cardiac, hepatic, skeletal, muscle, and renal disease. Highest LD levels are seen in persons with pernicious anemia, viral hepatitis, cirrhosis, and crush injuries.  
🗑
show Gamma-glutamyl-transferase (GGT)  
🗑
show Tissues ( Kidneys, brain, prostate, pancreas, and liver.) Urine contains a significant amount  
🗑
GGT is measured by what method?   show
🗑
show Elevated in almost all hepatobiliary disorders or biliary tract obstruction as well as in patients taking enzyme-inducing drugs like warfarin, phenobarbital, and dilatin  
🗑
show Increased GGT levels  
🗑
This enzyme is useful in the detection of alcoholism and the monitoring of alcohol intake by patients during treatment   show
🗑
show Amylase (AMS)  
🗑
Where is AMS distributed?   show
🗑
show Useful in diagnosis of acute pancreatitis. AMS levels rise 2 to 12 hours after the onset of an attack and peak at 24 hours.  
🗑
The measurement of radiant energy absorbed by a solution. This measurement can be related to the concentration of a substance in the solution.   show
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This measures the concentration through the detection of absorbance of electromagnetic radiation by atoms instead of molecules. It is used to measure concentration of metals that are not easily excited   show
🗑
the number of moles of particle per kilogram of water and depends only on the number of particles, not the types present.   show
🗑
Migration of charged particles in some medium when an electrical field is applied. Depending on the charge of the molecules, negatively charged particles migrate toward the positive electrode (anode) and positive charged move to the negative (cathode)   show
🗑
show Charge of molecule  
🗑
show Size of the molecule  
🗑
In electrophoresis, increased current increases what?   show
🗑
show migration rate  
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show Slows it down  
🗑
show Immunoassay  
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Technique used to separate complex mixtures on the basis of different physical interactions between the individual compounds and the stationary phase of the system. The goal is to produce "fractions" for quantitation.   show
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Semi-quantitative screening method   show
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Layer of absorbent material is coated on a piece of glass. spots of sample are applied. solvent is placed in container and migrates up the thin layer by capillary action.   show
🗑
show Rf = Distance component moves / (total distance - distance solvent front moves)  
🗑
show High Performance Liquid Chromatography  
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Separates mixtures of volatile compounds. Solvent is a gas, sample is vaporized, and detectors are thermal conductivity or flame ionization.   show
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Used in drug identification. Special detector can be used to measure the fragmentation patterns of ions.   show
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show Urea, Creatinine, uric acid  
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show Liver  
🗑
Involved with processing lipids. Composed of bile acids, salts, pigments, and cholesterol.   show
🗑
Where are bile salts formed?   show
🗑
show Gall-bladder  
🗑
show Bilirubin  
🗑
How is hemoglobin broken down?   show
🗑
Bilirubin found in the liver that is water soluble   show
🗑
show Conjugated bilirubin  
🗑
show jaundice  
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show PREHEPATIC jaundice  
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Present in people with hepatobiliary disease. This disorder exhibits increases in both unconjugated and conjugated bilirubin levels.   show
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show POST HEPATIC jaundice  
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show Cirrhosis  
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Liver destruction caused by viral infection, although the etiology of this disease is unknown. Ammonia accumulates in the liver and blood.   show
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Defined as inflammation of the liver and subsequent hepatocellular damage caused by bacterial infection, drugs, toxins, or viral infections.   show
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show Hepatitis A  
🗑
show Hepatitis B  
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Transmitted parenterally through blood transfusions, body piercings, and inoculations and has become more common. Leading cause of liver disease.   show
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The GI Tract is composed of what 5 regions?   show
🗑
show Intrinsic Factor  
🗑
Highly vascularized organ connected to the small intestine by the ampulla of Vater. Considered to be both an endocrine gland that synthesizes hormones and exocrine gland that provides digestive enzymes to aid in digestion   show
🗑
What type of cells produce glucagon?   show
🗑
What type of cells are responsible for making insulin?   show
🗑
show delta cells  
🗑
Breaks down starch and glycogen and is used to diagnose acute pancreatitis   show
🗑
show Lipase  
🗑
show trypsin  
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Autosomal recessive genetic disorder characterized by pulmonary disease and intestinal malabsorption caused by lack of pancreatic enzyme secretions   show
🗑
show Pancreatitis  
🗑
show Diabetes Mellitus  
🗑
Fatal disease that affects the ducts in the pancreas. Insulinoma is a tumor of the beta cells in the islets that leads to increased circulating insulin and hypoglycemia   show
🗑
show Secretin test  
🗑
show Quantitative fecal fat examination  
🗑
What specimen is collected for a Quantitative fecal fat examination   show
🗑
show Sweat electrolytes  
🗑
What is used to stimulate sweating on the skin during a sweat electrolyte test?   show
🗑
show 6.5 to 8.3 g / dL  
🗑
Most widely used method of protein determination   show
🗑
Cupric (Cu 2+) ions react with peptide bonds to form a violet color proportional to the number of peptide bonds present   show
🗑
Based on the ability of proteins to bind dyes. Albumin binds dyes with the strongest affinity   show
🗑
Caused by kidney disease, blood loss, malnutrition, and liver disease   show
🗑
Observed in people with dehydration or excess production of gamma-globulins   show
🗑
Caused by a variety of disorders, including a poor diet, liver dysfunction, GI inflammation, and renal disease   show
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show haptoglobin  
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show Ceruloplasmin  
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show Transferrin  
🗑
show Immunoglobulin  
🗑
Ions capable of carrying an electric charge   show
🗑
show Sodium  
🗑
Essential for transmitting nerve impulses   show
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show Renin-ADH system  
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Low blood volume induces secretion of renin, which induces production of aldosterone by the adrenal glands   show
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show hyponatremia  
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show hyponatremia  
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show hypernatremia  
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Major intracellular cation that regulates activity at the neuromuscular junction, as well as cardiac muscle contraction and pH.   show
🗑
show dietary intake  
🗑
Induces potassium reabsorption and secretion by the renal tubules by exchanging it for sodium   show
🗑
Low serum potassium, result of decreased dietary intake, gastrointestinal loss, or renal dysfunction. Can produced irregular heartbeat   show
🗑
show Hyperkalemia  
🗑
Major extracellular anion. Acts to maintain osmotic pressure, keeps body hydrated, and maintains electric neutrality via interaction with sodium or carbon dioxide   show
🗑
Moves chloride into RBCs as bicarbonate diffuses out to produce electro neutrality   show
🗑
Caused by salt loss during renal disease , diabetic ketoacidosis, or prolonged vomiting   show
🗑
Caused by dehydration, acute renal failure, prolonged diarrhea with loss of sodium bicarbonate, and salicylate intoxication   show
🗑
show Bicarbonate  
🗑
Major component of the blood buffering system. Accounts for 90% of total blood carbon dioxide, and maintains charge neutrality in the cell.   show
🗑
show Kidneys  
🗑
show Ion selective electrodes  
🗑
Silver ions are combined with chloride. Excess free silver ions are noted, elapsed time is relative to the chloride concentration   show
🗑
Difference between unmeasured anions and unmeasured cations. Normal range is 6 to 18 mmol.   show
🗑
Calculation of an Anion Gap   show
🗑
show Acid-Base balance  
🗑
Three physiological buffers act to maintain a constant pH :   show
🗑
show renal system  
🗑
show pH = pK + log ( cA / cHA )  
🗑
show Respiratory Acidosis  
🗑
Results from an increase in ventilation, resulting in excessive elimination of carbon dioxide. Compensation occurs by the kidneys excreting more bicarbonate.   show
🗑
Occurs in many disorders and results in a decrease in bicarb levels. The lungs compensate by hyperventilating.   show
🗑
Produced in many disorders and results from an increase in bicarb levels. Lungs compenstate by hypoventilation   show
🗑
These substances arise from the breakdown of proteins and nucleic acids   show
🗑
Major excretory product of protein metabolism and is synthesized in the liver from carbon dioxide and ammonia arising from the deamination of amino acids. Excreted by the kidneys   show
🗑
Typically caused by decreased renal blood flow to the kidneys from congestive heart failure, shock, dehydration, decrease in blood volume, greater protein breakdown, or high-protein diet   show
🗑
show Renal Azotemia  
🗑
show Postrenal Azotemia  
🗑
show Uremia  
🗑
show Creatine  
🗑
Anhydrous state of Creatine, which is excreted into the plasma in an amount proportional to muscle mass and then excreted in the urine.   show
🗑
Involves the reaction of Creatinine with picric acid to form a reddish chromogen. Absorbance is measured colorimetrically   show
🗑
Uses various enzymes and hydrogen peroxide to form a colored product   show
🗑
Estimate of the GFR obtained by measuring plasma Creatinine and its excretion into urine. Test requires a 24 hour urine specimen and blood sample for serum Creatinine determination.   show
🗑
Calculate Creatinine Clearance   show
🗑
show 10 to 20 : 1  
🗑
show Elevation of BUN is caused by Prerenal rather than renal causes  
🗑
Synthesized in the liver from the breakdown of nucleic acids and transported to the kidneys for reabsorption   show
🗑
show gout, increased nuclear breakdown, renal disease, or toxemia of pregnancy  
🗑
A decreased uric acid level is indicative of what?   show
🗑
Formed by the deamination of amino acids. Used by the liver to produce urea and is not excreted by the kidneys   show
🗑
show severe liver dysfunction or inadequate blood circulation through the liver  
🗑
show RED BLOOD CELL  
🗑
In the Zollinger-Ellison syndrome, is the gastric level increased or decreased:   show
🗑
show Vitamin D  
🗑
What is the most reliable method for methanol determination:   show
🗑
What term describes a decreased serum sodium:   show
🗑
show NO EFFECT  
🗑
What are the two end products of sucrose hydrolysis:   show
🗑
show TRANSPORTATION  
🗑
What solvents are used to extract the color due to Urobilinogen in the Watson-Swartz test?:   show
🗑
A patient has a blood pH of 7.23 and a pCO2 of 69 mm hg , what state is demonstrated by their values?   show
🗑
What is hypernatremia:   show
🗑
What is the hydrogen-ion selective membrane made of on the pH electrode:   show
🗑
show Kidney  
🗑
Bromcrestle green is used for the determination of what protein:   show
🗑
Is the serum lipase level in cystic fibrosis increased or decreased:   show
🗑
What enzyme hydrolyzes triglycerides:   show
🗑
show INTESTINES, LIVER, BONE, PLACENTA  
🗑
In a full term pregnancy is the lecithin-sphingomyelin ratio of 4:1 NL or ABNL:   show
🗑
show STIMULATE  
🗑
show TYROSINE  
🗑
What is a zwitter ion:   show
🗑
What organ produces albumin:   show
🗑
show CHLORIDE & BICARBONATE  
🗑
show BODY SURFACE AREA  
🗑
What alkaline reaction combines protein peptide bonds with copper ions?   show
🗑
show INDIRECTLY  
🗑
show DECREASED  
🗑
show HENDERSON-HASSELBALCH EQUATION  
🗑
What does the Zimmerman reaction measure:   show
🗑
Calcitonin has the opposite effect of what hormone:   show
🗑
What hormone lowers the level of Ca and Phosphate in the plasma and inhibits bone resorption:   show
🗑
What substance is analyzed using the phospho-tungstic acid:   show
🗑
What cation is most prevalent in normal human plasma:   show
🗑
In metabolic acidosis, is patient bicarb NL, INC, or DEC?   show
🗑
In what form is CO2 mainly transported in the blood?   show
🗑
What serum electrophoretic pattern is characteristic of nephrotic syndrome:   show
🗑
Is serum iron increased or decreased in hemolytic anemia:   show
🗑
Amino glycoside toxicity is associated with what organ:   show
🗑
What pigment is formed from the oxidation of Urobilinogen:   show
🗑
How is the level of thyroid binding globulin affected by pregnancy?:   show
🗑
show INCREASED  
🗑
Porphobilinogen is formed by the dehydrogenation of what acid   show
🗑
What form of bilirubin is carried by albumin in the blood and is insoluble in water? :   show
🗑
What is the function of Creatinine in the body:   show
🗑
show DECREASED  
🗑
Does hyperventilation occur in respiratory acidosis or alkalosis?   show
🗑
show COPPER  
🗑
What is the specific site of epinephrine synthesis:   show
🗑
show PITUTARY GLAND  
🗑
show NITROGEN, HYDROGEN, CARBON, OXYGEN  
🗑
Does pancreatic insufficiency exhibit an abnormal d-zylose?   show
🗑
Is a urine arsenic level of 50 mg per 24 hr NL or INC?   show
🗑
show SCURVY  
🗑
Is thymine a water soluble vitamin?   show
🗑
show INCREASED  
🗑
show LOWER BOTH  
🗑
What enzyme changes angiotensinogen to angiotensin:   show
🗑
In what area of the adrenal gland is cortisol synthesized:   show
🗑
show LIVER  
🗑
When light is absorbed at one wavelength and emitted at a longer wavelength, what is it called?   show
🗑
show GLYCOGEN  
🗑
What sugar when hydrolyzed yields glucose and Galactose:   show
🗑
show ZERO  
🗑
In a NL full term amniotic fluid, is there more lecithin or sphingomyelin?   show
🗑
In obstruction of the common bile duct is urine urobilinogen, NL, INC or DEC?   show
🗑
show OVARIES  
🗑
show 17-KETOSTEROIDS  
🗑
Name two substances that are inc in plasma and urine in pheochromocytoma:   show
🗑
show Hormone  
🗑
Collection of hormones, carrier proteins, and other components form what system:   show
🗑
How are hormones classified?   show
🗑
show thyrotropin-releasing hormone, cotricotropin-releasing factor  
🗑
Anterior pituitary   show
🗑
show vasopressin, oxytocin  
🗑
Adrenal medulla   show
🗑
show cortisol, aldosterone, 11-deoxycortisol  
🗑
show triodothyronine, thyroxine, Calcitonin.  
🗑
Parathyroids   show
🗑
show insulin, glucagon  
🗑
GI tract   show
🗑
Ovaries   show
🗑
Placenta   show
🗑
show testosterone , other androgens  
🗑
Kidneys   show
🗑
Are hormones water soluble or insoluble?   show
🗑
Do hormones require transport proteins to move through the blood?   show
🗑
show Steroid hormones  
🗑
show on or within a cell  
🗑
show prohormones  
🗑
Release of a hormone that regulated prior steps in the releasing process.   show
🗑
Steroid and thyroid hormones are bound to what?   show
🗑
show serum proteins and thyroxine-binding globulin  
🗑
show only the free portion  
🗑
What is responsible for hormone production?   show
🗑
show posterior pituitary  
🗑
Part of the CNS that lies at the base of the brain above the pituitary   show
🗑
Occurs when the stimulating hormone induces production of a hormone, elevated levels of which turn off pituitary release of the stimulating hormone.   show
🗑
show Positive feedback  
🗑
Primary disorders focus on what?   show
🗑
show disorders of the hypothalamus or may relate to ectopic production of pituitary hormones by nonendocrine tumors or to the hyposecretion of hormone by the target tissue.  
🗑
show pituitary dwarfism  
🗑
hypersecretion of FSH and LH can lead to what?   show
🗑
show Anti-diuretic hormone  
🗑
What is the adrenal cortex comprised of?   show
🗑
What are three adrenal hormones?   show
🗑
show glucocorticoids, mineralocorticosteroids  
🗑
show catecholamines  
🗑
show glucocorticoids and mineral corticosteroids  
🗑
Primary glucocorticoid produced and secreted by the adrenal cortex   show
🗑
What are the functions of cortisol   show
🗑
show kidney glomerulus and renal tubules, bone marrow stem cells, hepatocytes, and adipose tissue  
🗑
show bound to CBP and albumin  
🗑
What is the primary action of mineral corticosteroids   show
🗑
Primary mineralocorticoid produced and secreted by the adrenal cortex   show
🗑
What are the functions of aldosterone   show
🗑
What are the target tissues of mineralocorticoids?   show
🗑
show via the renin/angiotensin system  
🗑
show in the CNS  
🗑
What are the functions of catecholamines?   show
🗑
show liver and adipose tissue  
🗑
show vanillymandelic acid (VMA)  
🗑
Excess cortisol production, either at the level of the adrenal gland or by increased release of ACTH   show
🗑
Excess aldosterone production with symptoms of hypertension   show
🗑
Adrenal hypofunction or insufficiency   show
🗑
show Addison’s disease  
🗑
What is the major disorder of the adrenal medulla?   show
🗑
Bilobed endocrine gland located in the lower part of the neck that is composed of groups of cells called follicles   show
🗑
show thyroxine (T4) and triiodothyronine (T3)  
🗑
show Calcitonin  
🗑
What do thyroid hormones require for their synthesis?   show
🗑
show T3  
🗑
98% of circulating T3 and T4 is bound to what?   show
🗑
show brain  
🗑
show hypothyroidism  
🗑
Symptoms of this disease include: goiters, fatigue, impairment of mental processes, and loss of appetite   show
🗑
Inadequate secretion of thyroid hormones caused by a damaged or surgically removed thyroid gland   show
🗑
show secondary hypothyroidism  
🗑
This is caused by hypothalamic failure leading to a lack of TRH production   show
🗑
show Hashimoto’s disease  
🗑
show hyperthyroidism  
🗑
show hyperthyroidism  
🗑
Autoimmune disorder that occurs sex times more frequently in women than men. Immunoglobulins stimulate the thyroid gland by binding to TSH receptors.   show
🗑
show parathyroid hormone  
🗑
Mineral proved to be essential for heart muscle contraction, hemostasis, and cell responsiveness   show
🗑
Produced by parafollicular cells in the thyroid   show
🗑
Serum calcium levels rise to >102 mg/dL or are sustained at levels >100 mg/L.   show
🗑


   

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