Therapeuticmeds
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| pathophysiology-the cell | show 🗑
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| the cell adapts | show 🗑
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| The cell dies | show 🗑
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| show | 1.regeneration-replace injured tissue w/normal tissue-integrity and func restored 2. scarring-injured cells replaced by connective tissue-integreaty restored not function,
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| show | inflammation, proliferation and remodelling
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| show | 1. hemostatis-immediate vasoconstriction, activate platelets, control blood loss, 2.Vascular response-vasodialtion, incrase cell permeability, plasa exit vessel enter damaged tissue(edema), 3.cellular respons WBC clear the area of bacteria and dead cells
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| show | close the tissue wound-fibroblasts secrete collagen-protien that binds to self and other tissue to create scar, tissue becomes vascularized and new tissue cells form
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| Remodeling phase | show 🗑
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| show | 1.damaged cells release chemicals-histamine, bradykinins, prostaglandins, cause capillary dilation, increase cell permeability, 2reaction increase BF, plasma &protien enter interstitial space3.protiens in blood interact w.fibrin=collagen clot
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| show | chemicals attract luekocytes-prolong inflammation-act as phagocytes, dissolve absorb damaged cells 5. an inflammation continues, increase pressue, blood flow to ara decreased, damage to healthy cells in area=secondary hypoxic injury
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| Chronic inflammation | show 🗑
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| show | P!-tissue damage, inflammatory chemcisas, ischemia--Swelling, erthema, heat-increased blood flowk, plasma fluid in interstiial space-decreased function-p!, local muscle guarding, loos of movement--eccymosis-RBC in the tissue
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| show | arachidonic-produces prostoglandins-basodilate &sensitize receptors to bradykinins& histamin-decrease p!threshold, increased sensiati vity to p!
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| show | arachodoinic acid pathway-inflammation w/ asthma
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| show | COX1 enzyme-production of prostoglandins rsponsible for protection of GI mucosa, maintian renal function, platelet aggregation--COX2 enzyme-production of prostaglandins responsible for inflammation, pain, febver, wound healing
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| Non-Selective/traditional NSAIDs | show 🗑
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| Selevtive(celebrex, vioxx, Bextra) | show 🗑
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| NSAIDs | show 🗑
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| show | usted to treat-asthma, inflammatory bowel disease, tendonitis, bursitis, dermatolical conditions, allergic reactions-how-decreased inflammation by inhibiting synthesys of arachidonic acid-administerd-orally, inhal, inj, topical, transdermal
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| corticosteroid side effects | show 🗑
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| show | treats-midle/mod p!, fever--dosage-tablets, capsules, chewAVLE, SUPPORISTORES-side effects increase risk for liver toxivity, overdose-does not inhibit platelet aggregation like NSAIDs
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| analgesics-narcotics/opiates | show 🗑
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| Antibiotics | show 🗑
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| show | inhibits synthesis of bacteria cell wall, works to kill invading bacteria
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| Bacteriostatic | show 🗑
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| Antihistamines | show 🗑
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| show | tret allergies, cold, flue, skin-1st generation: lip soluble, pass blood-brain barrier=drowsy(benadryl), 2nd generation-less lip soluble less drowsiness(claritin, allegra)
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| show | reduce gastric acid production (H2 blockers)
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| Decongestants | show 🗑
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| decongestant side effects | show 🗑
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| show | used to treat-asthma, expand airways, relax bronchial spasm, admin-oral, inhaled(actquicker, fewer side effects) Side effects-side effects-tachycarda, increased BP, increased bloodsugar, nausea, vomit, nervousness, restlessness, diuretic
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| show | treat symptoms od diarrhea, not underlying cause, opoids-decrease GI motility(immodium),absorbents-absorbs h2o, increase viscosity of stoll
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| show | bulkform-fiber, swells when mixed w/h2o, stimlatesperistalsis-12-72 hrs, osmotic lax-draw h2o to intestinal lumen, increasae peristaltis 1-3 hrs, stimlant-increase bowelmotility, stomach cramps 6-10hrs, stool softeners-soften contents of bowel, prevention
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| Gi drugs-antacids | show 🗑
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| Proton Pump inhibitors(PPI) | show 🗑
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| H2 blockers | show 🗑
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| show | used to treat-superficial(mucous membrane, skin hair, nailes), systemic-side effects:oral:nausea vomit, abp!, HA, topical:itching burning, skin irritation
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| Fungicidals | show 🗑
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| show | prevent cell prlication, allows immune system to manage infection
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| show | prescription only, used to treat/reduce the duration/severity of: herpes virus, inluenza
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