AML
Help!
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| What are the types of translocation is AML associated with? | t(8;21) - RUNX,
inv(16),
t(15;17) - APL --> Down Syndrome,
t(9,11)
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| What is the median age for onset of AML? | 65 years
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| What is the cytoplasmic granule of AML? | Auer Rods
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| What are the CD Positivity? | CD 13,14 and CD33 positive
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| Which type of translocation is a favourable prognosis? | t(8; 21) - RUNX
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| What are the clinical findings Acute Promyelocytic Leukemia? | 1. Disseminated intravascular coagulation due to the release of thrombotic substance into the granules.
2. Younger age (median age 35-40).
3. t(15;17) translocation - APL-RAR
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| What Tx can be used for Acute Promyelocytic leukemia or T(15:17)? | All-trans retinoic acid (ATRA) can overcome the translocation.
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Created by:
Jameel D. Wilson
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