WVSOM Class of 2012 Intercellular Junctions
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| Numerous different linking proteins tie the membranes of adjacent epithelial cells closely together around their apical perimeters. What are these called? | tight junctions
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| tight junctions are also called what? | zoneal occludens
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| what are bound by 2 adaptor proteins and cadherins? | belt desmosome
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| multiple belt desmosomes anchor what? | circumferential belt
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| Constriction of these microfilaments around the “necks” of these cells pull them into a bottleneck shape: | circumferential belt
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| transmembrane complexes allowing diffusion of small molecules between cells are what? | gap junctions
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| isolated “spot welds” joining two cells at their lateral surfaces; serve to tie together the cytoskeletons of multiple cells across a tissue. what are these structures? | spot desmosomes
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| Complexes that anchor epithelial cells to the extracellular matrix of the basal lamina are what? | hemidesmosomes
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| structures that anchor microfilament stress fibers to the basal surface of fibroblasts and cancer cells which have attached to the substratum are what structures? | focal adhesions
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| what is a heterodimeric, transmembrane protein that binds a number of factors on both sides of the membrane? | integrin
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| these junctions seal epithelial layers against diffusion by preventing molecules from passing between the cells: | tight junctions
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| tight junctions also block passage of what? | components of the plasma membrane (lipids, proteins) between the apical and basal regions of epithelial cells
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| gap junctions have how many polypeptides per junction? what shape are they? | 12; hexagonal
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| what are some examples of molecules that pass through gap junctions? | calcium for muscles, ions for nerves, camp for many tissues
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| belt desmosomes are also called what? | adherens junctions
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| these link the microfilament cytoskeleton of one cell with that of another cell: | belt desmosomes
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| which desmosome is most like a focal adhesion? | belt desmosome
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| belt desmosomes anchor what fibers to the membrane? | microfilaments
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| in belt desmosomes, the filaments are linked to the same adaptor proteins used in what other junction? | focal adhesions
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| what are a family of calcium dependant transmembrane glycoproteins, often required for tissue specific cell-cell binding during development? | cadherins
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| belt desmosomes are linked by what? | cadherins
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| what are microfilament bundles attached to belt desmosomes, which encircle the apical perimeter of epithelial cells just below the tight junctions? | circumferential belt
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| what is an autoimmune disorder that attacks one of the transmembrane linker proteins in spot desmosomes? | pemphigus vulgaris
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| in hemidesmosomes, on the cytoplasmic side, intermediate filaments are bound to a pair of plaques consisting of what? | adaptor proteins
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| adaptor proteins in hemidesmosomes are held to the plasma membrane by integrin, which is tied to what? | laminin in the basal lamina
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| integrin is also used in focal adhesions where it links what to what? | microfilaments to fibronectin
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| in focal adhesions, on the outer side of the membrane, integrin binds what to link the cytoskeleton with the extracellular matrix? | fibronectin
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