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BYU PdBio 305 Dr. Rhees Reproduction

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Question
Answer
gonadal development depends on what   Y chromosome  
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how does the presence of a Y chromosome result in a male?   sex-determining region Y gene (SRY) is present on the short arm of the Y chromosome and ecodes for a protein called the Testis Determining Factor (TDF). This protein induces the formation of the testes  
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primary sex structures   ovaries, testes  
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development of secondary sex structures depends on   presence or absence of the hormone testosterone  
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androgens   testes secrete androgens and make male structures; ovaries can't secrete androgens resulting in female structures  
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wolffian ducts   up unti the 7th week of development, embryos of each sex posses wolffian ducts (form internal male structures  
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mullerian ducts   up unti the 7th week of development, embryos of each sex posses mullerian ducts (form internal female structures)  
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mullerian inhibiting factor   causes regression of the mullerian ducts; females become females because of lack of mullerian inhibiting factor and testosterone  
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human chorionic gonadotropin   hormone released by the placenta; stimulates early testicular secretion of testosterone which induces develpment of the wolffian ducts into the male reproductive tract (epididymis, ductus deferens, ejaculatory duct, and seminal vesicles)  
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male reproductive tract   epididymis, ductus deferens, ejaculatory duct, and seminal vesicles  
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female reproductive tract   oviducts, uterus, and vagina  
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external reproductive structures requre   dihydtrotestosterone or DHT  
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genitalia are mostly formed after how many weeks   16  
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differentiation of the male and female brain also depends on the presence or absence of what   testosterone  
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differences in male and female brain   size of hypothalamic nuclei, cyclic release of gonadotropin, and sexual behavior  
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how long does puberty last   3-5 years  
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menstruation started in 1840 at what age   17  
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sebaceous glands   stimulated to secreted oil (acne) during puberty  
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progesterone   female hormone related to menstruation period  
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precocious puberty   early puberty; early development of secondary sex characteristics; caused by abnormal exposure of immature females to estrogen or males to androgens; often caused by tumors of the gonads or adrenal glands  
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delayed puberty   menarche has failed to occur by age 17, testes failed to develop by age 20  
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spermatogenesis works best in what temp   colder  
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testes are divided into   testicular lobules (250 compartments)  
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Each lobule in the teste contains   a coiled seminiferous tubule and interstitial cells (Leydig cells)  
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function of seminiferous tubules   produce sperm; they also contain Sertoli cells which play a role in nurturing the sperm cells  
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function of Leydig cells   produce testosterone; are located outside of the seminiferous tubules  
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epididymis   small coiled tube which measures about 20 feet, lies along the top and side of the testes; site of maturation of sperm  
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capacitation   sperm's capacity to fertilize is enhanced by exposure to secretions of the female reproductive tract; the ductus epididymis also secretes "sperm forward-mobility protein," which causes a movement pattern of the sperm  
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vas deferens (ductus deferens)   tubes that carry sperm from the epididmis up into the abdominal cavity to the ejaculatory duct near the bladder; at the end of the vas deferens is an expanded region called the "ampulla" which serves as a reservoir for sperm  
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vasectomy   a small incision is made in the scrotum, the vas deferens is tied in two places and the segments between the ties are removed  
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Ejaculatory ducts   carry sperm from vas deferens to urethra  
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urethra   tube extending from the urinary bladder through the flor of the pelvic cavity and then through the penis; carries urine from bladder and sperm from ejaculatory duct  
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male sex accessory organs   seminal vesicles, prostate gland, bulbourethral glands; these glands secrete seminal plasma which mixes with the sperm to form semen or seminal fluid  
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seminal vesicles   secrete seminal plasma (more than half of total semen volume); fluid contains fructose to give energy to sperm; fluid also contains prostaglandins which stimulate contraction of the male and female reproductive tracts which helps in sperm transport  
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prostate gland   lies below the bladder and is doughnut shaped; urethra pases through the small hole in the center; secretes alkaline fluid (13-33% of volume) that helps protect the sperm from the acidic environment of the male urethra and female vagina  
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bulbourethral glands   secrete alkaline fluid, which acts as a lubricant  
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male fertility   depends on quantity and quality of sperm; 2-6 ml, 20 million sperm/ml, 60% normal shape  
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number of sperm produced daily   200 million/day  
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sperm live how long   3-4 days  
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sperm count per ejaculation   40 million to 250 million; below 20 million may mean infertility problems  
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how many sperm enter fallopian tube   100-100,000  
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how many sperm make it to the egg   few hundred  
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zygote   fertilized egg  
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what happens to dead sperm in female   phagocytized by leukocytes  
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infertility is due to whom   50% man 50% woman  
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structure of sperm   head (contains nucleus with 23 chromosomes), acrosome (enzyme filled vesicle), tail (for movement), midpiece (contains a large number of mitochondria)  
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uterus   pear shaped organ situated in the pelvic cavity above the urinary bladder and in front of rectum- 3 inches long, 2 wide, 1 thick; larger in multiparous women  
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two main regions of the uterus   corpus or body, uterine isthmus or cervix (neck)  
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two main components of the wall   endometrium (shed during menstruation) and myometrium (smooth muscle, contraction of the uterine wall results in expulsion of the fetus at birth  
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fallopian tubes, oviducts, or uterine tubes   serve as ducts for ovaries (diameter of drinking straw); fertilization usually takes place there)  
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ovaries   among the most vascular organs of the body  
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ovarian follicles   female germ cells or oocytes are enclosed inside the ovary in tissue sacs called ovarian follicles  
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how many follicles do newborn girls have   500,000  
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how many follicles are released through ovulation   400  
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ovulation   production of mature egg;when there is estrogen present, the immature oocyte will go from a primary, to secondary, to tertiary follicle. the large follicle that develops during the cycle is called a graafian follicle. It is this follicle that breaks ope  
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secretion   production of female hormones  
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Estrogen   estradiol, estrone, and estriol; estradiol is the principle estrogen; produced by follicle, corpus luteum, and plaenta, stimulates development of secondary sex structures, promote myometrial contractions, inhibit FSH secretion  
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progesterone   produced by corpus luteum and placenta; stimulate development of secondary sex structures; inhibits contraction of uterine muscle  
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average human menstrual cycle length   29.5 days  
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day 1 of ovarian cycle   menstruation starts, estrogen and progesterone levels are low, FSH stimulates the development of the follicle (the egg inside the follicle), several follicles start to develop-follicle secrete estrogen  
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day 7 of ovarian cycle   usually only one follicle continues to develop and secrete estrogens; others degenerate; estrogen elvels increase as the folicle grows into a graafian follicle;several days before ovulation, more LH are releases from anterior pituitary  
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day 14 of ovarian cycle   high levels of LH stimulate ovulation; LH surge occurs 16 hours before ovulation; expulsion of egg from the mature follicle--ovaries usually alternate  
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indications of ovulation   rise in basal body temperature due to progesterone; slight pain over ovary; vaginal secretory pattern  
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fertile period length   4-6 days  
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destiny of follicle cell after ovulation   LH stimulates the transformation of follicle cell into a corpus luteum (yellow body)  
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cells of corpus luteum secrete   estrogens and progesterone  
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day 23 of ovarian cycle if pregnancy occurs   the corpus persists; Human chorionic gonadotrophin (HCG) maintains the corpus luteum during pregnancy, which in turn maintains the levels of estrogen and progesterone  
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HCG   human chorionic gonadotrophin; is detectable in the blood and urine as early as 8-10 days after fertilization so it's used in pregnancy kits; similar to GH and prolactin; has anti-insulin effects to divert glucose from mother to fetus  
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day 23 of ovarian cycle if no pregnancy   corpus luteum begins to degenerate on about day 23 or 24; with degeneration of the corpus luteum, the levels of estrogens and progesterone drop  
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day 27 of ovarian cycle (no pregnancy)   low levels of estrogen and progesterone cause ischemia in the endometrium, which initiates the beginning of the next cycle in one to two days  
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menstrual cycle names   day 1-5 menstrual phase; 6-14 postmenstrual, preovulatory, or follicular phase; day 14 ovulation; day 14-27 premenstrual, postovulatory, or luteal phase; day 27-28 ischemic phase  
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implantation takes place how many days after fertilization   6-7 days  
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intrauterin implantation   usually implants in the upper posterior wall of uterus; cervical implantation  
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extrauterine implantation   rare; called ectopic pregnancy (anywhere outside the uterus); tubal, abdominal, ovarian  
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pregancy lasts how long   38 weeks (9.5 months)  
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pre-embryo   first 2 weeks after conception  
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embryo   3-8 weeks after fertilization; most critical period for damage to occur to baby  
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how much weight should a pregnant mother gain   25 pounds  
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during pregnancy, which hormones increase   estrogens, progesterone, HCG (human chorionic gonadotrophin which peaks at 2nd month), Glucocorticoids from the adrenal glands, T3 and T4 from thryoid, parathyroid hormone  
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change in pituitary during pregnancy   increases in size and activity  
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change in blood volume and cardiac output during pregnancy   increase  
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parturition   act of giving birth  
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factors that increase contractibility of the uterus   increased estrogen levels, secretion of oxytocin from posterior pituitary, formation of prostaglandins in the uterus  
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labor is divided into three stages   1)cervical dilation-up to 10 cm 2)delivery of the baby 3)delivery of the placenta (afterbirth)  
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when does menopause start   52  
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menopause (what happens)   follicle does not develop and therefore LH and FSH remain high and estrogens and progesterone remain low  
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treatment for menopause   estrogen replacement therapy using premarin; there's recent evidence that ERT might not be so good  
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benefits of ERT   relieves hot flashes, insomnia, vaginal dryness, mood swings, and heart disease  
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risks of ERT   increased risk of endometrial and breast cancer, weight gain, and gall bladder disease  
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tubal ligation   tying off both uterine tubes and thus preventing the transport of sperm or egg through the tubes  
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