MLT Serology unit 6.1 Immune System
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| show | The study of all aspects of body defenses, such as antigens and antibodies, allergy, and hypersensitivity.
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| Antigen (Immunogen) | show 🗑
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| show | Specific glycoproteins produced in response to an antigenic challenge.
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| Antigenicity | show 🗑
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| show | The process of being protected against foreign antigens.
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| show | A condition in which the body's own antigenic structures stimulate an immune response and react with self antigens in a manner similar to the destruction of foreign antigens. This process may cause autimmune disease.
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| Antigenic Determinants | show 🗑
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| show | The portion of the molecule that the body recognizes as an antigen. It is functionally the portion of an antigen that combines with an antibody paratope (the part of an antibody molecule that makes contact with the antigenic determinant)
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| show | A low molecular weight molecule that can combine with another molecule to produe an antibody response. These substances are antigenic only when coupled to a protein carrier.
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| show | A molecule, that when coupled with a hapten, renders the Hapten immunogenic.
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| Lymphokine | show 🗑
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| show | Serum proteins that attach to a foreign substance and enhances phagocytosis (C3b). WHen the complement component C3b is attached to a particle, it promotes the adherenc of phagocytic cells because of the C3 receptors.
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| Adjuvant | show 🗑
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| show | 1-Foreigness, 2-Degradability, 3-Molecular Weight, 4-StructuralStability, 5-Complexity
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| What is the degree to which an antigen is recognized as non-self by the immune system? | show 🗑
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| T/F Foreign molecules destroyed rapidly will not present long enough to provide adequate antigenic exposure (degradibility) | show 🗑
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| T/F - The higher the molecular weight the better the molecule will function as an antigen | show 🗑
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| Structural stability | show 🗑
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| Complexity | show 🗑
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| Which molecules are the most immunogenic? | show 🗑
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| Which molecules are weakly immunogenic? | show 🗑
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| What is Auto-antigens ? (AKA "Auto-imunity", "Autologous") | show 🗑
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| What is second only to ABO antigens in influencing survival or rejection of transplanted organs? | show 🗑
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| What type of antigens are distributed throughout tissues, blood cells and body fluids? | show 🗑
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| What are antigens found in unrelated plants and animals which are identical or closely related? (Rection termed "cross reaction") | show 🗑
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| What is a specific glycoprotein produced in response to antigenic situations, and has specific interactions with prvoking antigens? | show 🗑
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| How are antibodies structured? | show 🗑
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| HOw are antibodies named? | show 🗑
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| What are the names for the classes of heavy chains? | show 🗑
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| What are the names for the classes of light chains? | show 🗑
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| Which chain is responsible for Bence-Jones proteins found in urine of Multiple Myeloma patients? | show 🗑
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| show | Papin and Pepsin
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| What part of an antibody is capable of antigen binding and contains one light chanina nd half of a heavy chain? | show 🗑
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| Which portion of an antibody will crystallize and contains only the constant region of the heavy chain? | show 🗑
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| show | Hinge Region
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| Which region of an antibody is located in the FAB portion and has amino acid sequences that varies? | show 🗑
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| show | Constant region
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| show | They are named for their heavy chains class
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| Which antibody is the major immunoglobulin in normal serum? | show 🗑
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| Which immunoglobuin has 4 sub-classes and makes up 70%-75% of the total immunoglobulin pool? | show 🗑
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| show | IgG
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| Which immunoglobulin makes up about 10% ofthe total immunogloblin pool and is the first antibody produced in an immune response? | show 🗑
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| show | IgM
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| show | IgA
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| show | Secretor antibody
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| show | IgD
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| show | IgE
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| Which antibodies has the monomer or "Y" shape? | show 🗑
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| show | IgA
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| show | IgM
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| What are the 4 functions of antibodies? | show 🗑
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| show | Serum, at least 3ml
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| What type of specimens would be rejected when performing antibody testing? | show 🗑
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| What phase of infection does IgM usually appear in? | show 🗑
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| show | Serum, at least 2ml
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