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Blood Cells SG
Blood Cells
| Question | Answer |
|---|---|
| Where do red blood cells and platelets solely work? | In the vasculature |
| Describe the role of platelets | Platelets police vasculature to find rips in endothelial lining. They plug up the site. |
| How does leukocyotes use the vasculature? | Use it to make their way to site of action. Look for bacterium putting out hemo-attractants. |
| When does the level of neutrophils increase? | When there is bacterial infections. They phagocytize the bacterium. |
| What are the three layers of the blood vessel? | Tunica intima, endothelial layer and connective tissue |
| Where are RBC's located at peak of blood flow? | Center of the vessel |
| Describe the term cytopenia | Decrease in number |
| Cytosis | Excess |
| Describe thrombasthenia | Normal number of platelet cells but they are defective. Wrap integrin molecule so they can't aggregate. |
| What does a CBC test look for? | Looking at complete blood count |
| Do you get a fibrin clot when you block coagulation? | No |
| What are the three layers when you spin blood in a tube? | RBC's on the bottom, Plasma is the top yellow coat. Buffy coat in between RBC and plasma cells |
| What does the buffy coat contain? | WBC's and platelets |
| What does plasma cells contain? | Water is majority. Proteins: Albumin, Globulin, Fibrinogen, Complement and Electrocytes |
| True or False: Red blood cells have a nucleus | False. They were extruded during maturation. only hemoglobin left |
| Describe the role of spectrin | Links to sites of protein on plasma membrane. Important in maintaining RBC shape. If destroyed then RBC cells become spherical and lose disc shape. |
| What is hereditary elifocytosis | Defect in band 4.1 of spectrin |
| If you have N-actely galactosamine what blood type are you? | Type A |
| If you have galactose what blood cell type are you? | Type B |
| What type of cells is IgE associated with? | Basophils and mast cells |
| What happens when moncytes escape into the underlying tissue? | They transform into macrophages |
| List macrophages derived from a blood monocyte | Kupffer Cell: Liver. Osteoclasts: Bone. Microglial: Brain. Langerharn: Skin. |
| What do all antigen presenting cells have? | MHCII |
| What is the first cell that goes forth during an inflammatory response? | Neutrophil |
| What is the goal of neutrophils in response to bacteria? | To phagocytize tissue debris |
| What do primary specific granules do? | Fuse with the bacterium |
| What happens when bacterial cells send out a chemoattractant? | Signals endothelial cells to start changing activating intergins, Increasing adhesion causes neutrophils to stop rolling and make its way through the junction. |
| Describe chemotaxis | The neutrophil makes its way to the bacteria |
| Describe opsonization | The coating of the foreign particle with proteins that will be recognized by neutrophils. Antibodies and complement factor are in the coat. |
| How do neutrophils recognize the antibody and complement? | It has a Fc receptor which triggers to phagocytize the bacteria |
| When IgE coats allergens what response does this trigger? | Basophils and mast cells to secrete histamine and heparin sulfate |
| What cell is associated with IgG? | Neutrophils |
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