Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
une ch 8
enzymes as catalysts
| Question | Answer |
|---|---|
| Be able to name the 6 major classes of enzymes. | HOTILL 1. Hydrolase 2. Oxidoreductase 3. Transferase 4. Isomerase 5. Lyase 6. Ligase |
| Oxidoreductase | Alcohol dehydrogenase |
| Transferase: | Glucokinase |
| Hydrolase | Chymotripsin |
| Lyase | Aldolase |
| Isomerase | Triosephosphate isomerase |
| Ligase | Pyruvate Carboxylase |
| write the equation for the first step in alcohol metabolism in humans and then explain in words | CH3CH2OH + NAD+ = CH3CHO + NADH + H+ Ethanol is oxidized to acetaldehyde while NAD+ is reduced to NADH. |
| thiamine pyrosphate | an activation transfer coenzyme (helps catalysis by forming covalent bond w substrate), synth by thiamine, attacks alpha keta acids, breaks C-C bond btw carbon and carboxyl carbon |
| CoA | activation transfer enzyme synthesized by vitamins (pantothenate), functional group is the sulfylhydryl group which forms thioester bonds with carboxylic acids, and acyl groups are activated |
| biotin | is the vitamin and coenzyme. covalently bonded to a lysine in enzymes called carboxylases, functional group is a nitrogen that covalently bonds to a co2 group |
| pyridoxal phosphate | vitamin pyridoxine (vitamin B6). the reactive aldehyde group usually functions in enzyme catalyzed reactions by forming a covalent bond with amino groups on amino acids. |
| NAD+ | synth from niacin and ATP. ADP binds tightly to enzyme-causes conformational changes. |
| how does DFP (nerve gas) work? | it forms a covalent intermediate that binds to active site of acetylcholesterase-thereby preventing it from degrading AcH. this is irreversible. |
| how does penicillin work? | it is a transition state analog that binds tightly to glycopeptidyl transferase |
| why is penicillin a suicide inhibitor? | suicide inhibitor= irreversible inhibitor-it binds and forms covalent bond w serine at the active site |
Created by:
carolanimal