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NAPLEX - HIV - 1

HIV Drug Side Effects

QuestionAnswer
Fusion Inhibitors bacterial pneumonia, injection site reaction hypersensitivity
CCR5 Antagonists CNS-2, hepatotoxic, cough, muscle/joint pain
Selzentry dosing based on concomitant 3A4 inhibitors/inducers
Non-Nucleoside Reverse Transcriptase Inhibitors/NNRTIs CNS-2, GI-2, hepatitis, increased LFTs, rash/SJS
Sustiva/efavirenz hallucinations, dreams, hypertriglyceridemia
Intelence/etravirine peripheral neuropathy
Viramune/nevirapine hepatotoxicity (increased risk for MEN w/ CD4 > 400 & for WOMEN w/ CD4 > 250)
Sustiva/efavirenz take on empty stomach
Nucleoside/-tide Reverse Transcriptase Inhibitors/NRTIs CNS-2, GI-2, hepatic steatosis (fatty liver), hyperlipidemia Other: lipodystrophy, lactic acidosis
Viread/tenofovir nephrotoxic
Videx/didanosine retinal changes, pancreatitis, portal HTN, peripheral neuropathy
Videx/didanosine weight based dosing, take on empty stomach
Retrovir/zidovudine macrocytic anemia, neutropenia, hyperpigmentation (nails/mucosa)
Zerit/stavudine DM, neuromuscular weakness, peripheral neuropathy
Emtriva/emtricitabine hyperpigmentation
Ziagen/abacavir increased risk of MI, hypersensitivity reaction (more likely w/ HLA-B*5701 allele)
Which NRTIs have anti-hep B activity? TDF/tenofovir/Viread FTC/emtricitabine/Emtriva 3TC/lamivudine/Epivir
Integrase Inhibitors GI-2, transaminitis, may increase CK (myopathy, rhabdo) though uncommon
Protease Inhibitors CNS-2, CHD, stroke, hyperlipidemia, hyperTG GI-2, hepatitis Endo: DM Other: increased bleeding in hemophiliacs
Reyataz/atazanavir PR prolongation, increased indirect bilirubin, needs an acidic environment, take with food Derm: rash Other: kidney stones, fat maldistribution
Prezista/darunavir rash/SJS - SULFA MOIETY!!!
Lexiva/fosamprenavvir rash - SULFA MOIETY!!!; Other: paresthesias, fat maldistribution
Crixivan/indinavir increased bili, gallstones, alopecia, poor bioavailability (take on empty stomach, multiple daily dosing) BMS: hemolytic anemia Other: kidney stones, musculoskeletal pain
Kaletra/lopinavir+ritonavir pancreatitis
Aptivus/tipranavir BBW for intracranial hemorrhage SULFA MOIETY
Created by: mktaylor87411
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