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Cells & Tissues
Cell Cycle & Mitosis-Test #1
Front | Back |
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The Life Span of a cell includes? | Mitosis-cell division; Interphase-most of the time the cell is in this cycle |
What is interphase ? | The period that covers all the time the cell is not undergoing mitosis |
What is Mitosis? | The orderly events that involve the division of the nucleus |
What are the diff. phases of the cell cycle? | G0, G1, G2, S |
G1 Phase (pre) | Variable in length (1 yr, hrs, days); Protein Synthesis; Regains normal size-Cell Growth; Checkpt. prior to entry to S phase (is enviro. favorable for division? is DNA intact?) |
S Phase | DNA is replicated; 6-8 hrs. in length; Semiconservative Replication (old & new strands) |
G2 Phase (post) | Completes preparation for cell division; 3-6 hours in length; Synthesis of tubulin for microtubules; Checkpt. for repair of DNA (has DNA totally replicated?) |
M Phase | Mitosis; 1-2 hours in length |
G0 | Entered from G1; Cell is not dividing but still active b/c there's sufficient supply of that type of cell; Cardiac muscle and neurons permanently in G1 |
The cell cycle is regulated by what? | External and Internal factors |
External Regulation | Specific receptors on the cell surface send cytoplasmic signals to cellular components to divide |
Internal Regulation | Regulated by Cyclins & Maturation promoting factor (MPF) |
What are cyclins? | Proteins that bind to specific kinases to regulate events of interphase (cell cycle) |
What is MPF? | cyclin M + kinase; Rapid increase of the protein triggers cell entry into Mitosis |
Mitosis is made up of what two main stages? | Karyonkinesis-nuclear division and Cytokinesis-division of the cytoplasm |
Karyokinesis has how many stages? | 4-Prophase, Metaphase, Anaphase, Telophase |
Prophase | Chromosomes appear; Nuclear envelope breaks down; Centrosomes separate to opp. poles |
Metaphase | Chromosomes migrate to Equatorial Plane; Chromosomes separate into sister chromatids |
Anaphase | Chromatids move to opp. poles; Cytokinesis begins |
Telophase | Chromosomes disperse; Nuclear envelope regenerated; cytokinesis completed |
What is cytokinesis? | The division of the cytoplasm during Mitosis |
What occurs in the cell during cytokinesis? | Band of actin filaments form at equatorial plane; constriction of band separates cytoplasm; begins at anaphase and end in telophase |
What is Apoptosis? | Programmed cell death |
Apoptosis can occur during what two stages of life? | Embryonic development and Adult Life |
Apoptosis in Embryo Develop. | Normal reorganization of tissues; Ex. developing hand & foot once those are completed not all cells used to form are needed |
Apoptosis in Adult Life | Occurs to balance cell divisions; removes cells that are damaged or ineffective; Nucleus condenses and breaks up; Does NOT initiate an inflammatory response |