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Mode of Action -
Classification of modes of action of antibiotics
Question | Answer |
---|---|
Sulfonamides | competitors for metabolic pathways. Inhibit PABA pathways. Drugs: Sulfanilamide and Trimethoprim |
Aminoglycosides | Inhibit protein synthesis. Causes misreadins and blocks initiation. Drugs: streptomycin, kanamycin, neomycin, gentamycin, tobramycin |
Tetracyclines | Inhibits protein synthesis. Binds to 30s ribosome near the codon, prevents docking of tRNA. Broad spectrum |
Chloramphenicol | Inhibits protein synthesis. Inhibits peptidyl-transferase. Broad spectrum |
Macrolides | Inhibits protein synthesis. Binds to 50s ribosome in the e-site to prevent the mRNA from exiting. Drugs: erythromycin, azithromycin, olendomycin, telithromycin, and carbomycin. |
PolymoxinB | Inhibits membrane function/activity. Amphipathic. Used topically. |
Polyene antimicrobial | Inhibits membrane function/activity. Binds to ergosterol. Drugs: amphotericin B and nystatin |
Rifamycin | Inhibits nucleic acid synthesis. Prevents production of RNA. Drug: Rifampin. |
Metronidazole | Inhibits nucleic acid synthesis. Inserts into DNA and breaks it apart |
Nalidixic Acid | Inhibits nucleic acid synthesis. used to form quinolones and fluoroquinolones as semi-synthetics. These inhibit Gyrase and Topoisomerase II |