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Mode of Action -

Classification of modes of action of antibiotics

Sulfonamides competitors for metabolic pathways. Inhibit PABA pathways. Drugs: Sulfanilamide and Trimethoprim
Aminoglycosides Inhibit protein synthesis. Causes misreadins and blocks initiation. Drugs: streptomycin, kanamycin, neomycin, gentamycin, tobramycin
Tetracyclines Inhibits protein synthesis. Binds to 30s ribosome near the codon, prevents docking of tRNA. Broad spectrum
Chloramphenicol Inhibits protein synthesis. Inhibits peptidyl-transferase. Broad spectrum
Macrolides Inhibits protein synthesis. Binds to 50s ribosome in the e-site to prevent the mRNA from exiting. Drugs: erythromycin, azithromycin, olendomycin, telithromycin, and carbomycin.
PolymoxinB Inhibits membrane function/activity. Amphipathic. Used topically.
Polyene antimicrobial Inhibits membrane function/activity. Binds to ergosterol. Drugs: amphotericin B and nystatin
Rifamycin Inhibits nucleic acid synthesis. Prevents production of RNA. Drug: Rifampin.
Metronidazole Inhibits nucleic acid synthesis. Inserts into DNA and breaks it apart
Nalidixic Acid Inhibits nucleic acid synthesis. used to form quinolones and fluoroquinolones as semi-synthetics. These inhibit Gyrase and Topoisomerase II
Created by: laurenneed