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Hepatitis - LIU

3rd packets

What organ involves hepatitis? Liver
What family does Hepatitis A (HAV)? Piconaviridae
What family does Hepatitis B (HBV)? Hepadnaviridae
What family does Hepatitis C (HCV)? Flaviviridae
What family does Hepatitis D (HDV)? Deltavirus
What are the common symptoms of hepatitis? Fever, GI symptoms, Nausea and Vomiting
Hep A's Mode of transmission? Fecal-oral, in crowded populations with poor sanitation Rarely through needles, it's viremia is very short
Is Hep A oncogenic, which types are? No, type B and C are oncogenic
Name of the vaccine for Hep A? Formalin inactivated HAV vaccine
What type of DNA is in Hep B and why is it incomplete? ssDNA positive strand and circular incomplete until it infects a new cell
What are the conditions of Hep B? Cirrhosis and carcinoma of the liver
Hep B's Mode of transmission? Parenteral - Needles, Transplants, tattoo's and even sexually and orally, also mother-son
What are the 3 morphologic forms of Hep B, known as the dane particles? Spherical, Pleomorphic spherical and filamentous
What is the outer surface antigen of Hep B? HBsAg
Why is HBsAg important for Hep D? Because it provides HbsAg envelope for it
What is Fulminant Hepatitis? Combination of Hep B and D (Co-infection)
What genes are contained in Hep B? Transactivator protein X Polymerase P - (RNase H and reverse transcriptase S gene - encodes HBsAg C gene - encodes HBcAg and HBeAg
What is cccDNA in Hep B? covalently closed DNA, it happens after the incomplete DNA closes
Types of Vaccine for Hep B? Recombinant HBsAg vaccine Hepatitis B immune globulin (Passive) HBsAG at different site soon after exposure (Active)
Medication for Hep B? Interferon alfa Antivirals (entecabir, adefovir, lamivudine, ribavirin
What is the difference in Hep B infection between effective and limited T cell immunity? Effective: acute hep Limited: chronic disease (Cirrhosis or carcinoma)
Which hepatitis does not have an arthropod vector? Hep C
How is Hep C transmitted? Parenteral - transfusion of blood products, semen, mother-son, hemodialysis, sex
What is the primary cause of chronic liver carcinoma? Hep C
What is the treatment for Hep C? Similar to Hep B, Interferon Alfa and ribavirin
What are the types of vaccine for hep C? None
Why can't Hep D exist by itself? Because it needs the envelope of HBsAg, the only gene on the molecule codes for HD-AG
What kind of RNA is in HDV? ssRNA
What kind of RNA is in HAV? ssRNA
What kind of RNA is in HBV? dsDNA
What kind of RNA is in HCV? ssRNA
What are the vaccines for HDV? There is no specific vaccine, it needs HBV to coexist so by targeting HBV the infection can be stopped.
Created by: studypharm