Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
HIV Pharm
Pharm-II
| Question | Answer |
|---|---|
| How is HIV transmitted | blood, semen, vaginal fluid, breast milk, body fluids |
| What body fluids may health care workers be exposed to | cerebral spinal fluid, synovial fluid, amniotic fluid |
| What are actual routes HIV is transmitted yb | Sex, IVDUs, occupational, mother-to-child (MTCT) |
| What increases the probablility of transmission | higher viral load at transmission,type of needle |
| What are mis conceptions of HIV transmission | trx w/ casual contact, ARVT means cure, post exposure is effective prevention, ↓ loads eliminates risk, HIV invected individuals can have sex w/ each other, can tell HIV + by appearance |
| When is PEP indicated and % effectiveness | within 72 hrs exposure, and ~80% for seroconversion |
| What is ARS and when does it present | acute retroviral syndrome “primary infection”, presents 1-4weeks after infection |
| Hallmark signs of acute phase | high viral load, rapid dissemination to lymphoid tissue, ↓ CD4 cells –ab during this infx |
| Two HIV entry inhibitors | Enfuvirtide, Maraviroc |
| Indications for HAART therapy | Hx AIDS-defining illness, CD4 <350, pregnancy, HIV-associated nephropathy, Hep B infx requiring tx |
| When can we potentially initiate ARVT therapy | CDV cells <500 (optimal start is unknown) |
| Benefits for early therapy | prevent HIV-related end organ damage, may ↓ other co-morbidities/complications |
| Potential drawbacks of early therapy | toxicities?, non-adherance: drug resistance, costs |
| 3 preferred ARVTx combos | INSTI + 2 NRTIS, PI + ritonavir + 2 NRTIs, NNRTI + 2 NNRTIs |
| Monitoring aspects | CD4 count and viral load |
| What classifies as tx failure | VL >400copies/mL @ 24weeks OR VL 48-78 copies @ 48 weeks |
| How do HIV drugs fail | improper administration/absorption, storage, missing doses |
| How do we test for HIV resistance (3) | genotype, phenotype, virtual phenotype |
| Tests pt specific HIV sample with ARVs | Phenotype expensive, takes up to 1 month |
| Who should treat HIV pt’s with highly treatment-experienced HIV virus? | HIV specialist, or HIV medical provider |
| What are non-aids associated issues | CVD, metabolic, renal, non-aids malignancies, liver dz |
Created by:
becker15
Popular Clinical Skills sets