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Male Repro Pathology

Bakhtar-Male Reproductive Pathology

seminoma most common pure germ cell tumor identical to dysgerminoma gray-white lobulated cut surface large round cells, clear cytoplasm, large nuclei, prominent nucleoli in dense background of lymphocytes secrete hCG
spermatocytic seminoma germ cell tumor unrelated to "classic" seminoma no metastatic potential three cell types: medium, small, giant
embryonal carcinoma germ cell tumor can be aggressive often hemorrhagic undifferentiated cells growing in alveolar or tubular pattern
yolk sac tumor germ cell tumor counterpart of endodermal sinus tumor in females most common testicular tumor in children < 3 y.o. Schiller Duval Bodies Secrete AFP
choriocarcinoma germ cell tumor highly malignant tumor hemorrhagic and necrotic syncytiotrophoblasts (secrete hCG) and cytotrophoblasts
teratoma germ cell tumor benign and/or malignant components from more than one germ cell layer can have mature/immature elements can have respiratory elements differentiated teratomas in males: -children: benign -post-pubertal: malignant
leydig cell tumor sex cord tumor secretes androgens
lymphoma most common testicular tumor in patients > 60 y.o. most common is diffuse large B-cell lymphoma
mixed tumor germ cell tumor most common testicular tumor prognosis worsens based on type of cancer
seminoma vs non-seminoma seminoma: often present at low age, primarily lymphatic route of spread, radiosensitive non-seminoma: often present at high age, primarily hematogenous route of spread, radioresistant
cryptochordism failure of intra-abdominal testis to descend two phases: transabdominal and inguinosacral (the most common) 75% unilateral increased risk of cancer in both testes
hypospadias congenital defect urethral opening on underside of penis
epispadias congenital defect urethral opening on topside or bottom side of penis
phimosis foreskin can't be retracted fully over glans penis
testicular torsion twisting of spermatic cord venous drainage blocked and increased arterial pressure-->hemorrhagic infarct testis remain viable if untwisted within 6hrs underlying malignancy should always be excluded
condyloma skin disease HPV-related dysplasia: HPV 6 and 11 display koilocytic atypia
Created by: kphom001