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Male Repro Pathology
Bakhtar-Male Reproductive Pathology
| Question | Answer |
|---|---|
| seminoma | most common pure germ cell tumor identical to dysgerminoma gray-white lobulated cut surface large round cells, clear cytoplasm, large nuclei, prominent nucleoli in dense background of lymphocytes secrete hCG |
| spermatocytic seminoma | germ cell tumor unrelated to "classic" seminoma no metastatic potential three cell types: medium, small, giant |
| embryonal carcinoma | germ cell tumor can be aggressive often hemorrhagic undifferentiated cells growing in alveolar or tubular pattern |
| yolk sac tumor | germ cell tumor counterpart of endodermal sinus tumor in females most common testicular tumor in children < 3 y.o. Schiller Duval Bodies Secrete AFP |
| choriocarcinoma | germ cell tumor highly malignant tumor hemorrhagic and necrotic syncytiotrophoblasts (secrete hCG) and cytotrophoblasts |
| teratoma | germ cell tumor benign and/or malignant components from more than one germ cell layer can have mature/immature elements can have respiratory elements differentiated teratomas in males: -children: benign -post-pubertal: malignant |
| leydig cell tumor | sex cord tumor secretes androgens |
| lymphoma | most common testicular tumor in patients > 60 y.o. most common is diffuse large B-cell lymphoma |
| mixed tumor | germ cell tumor most common testicular tumor prognosis worsens based on type of cancer |
| seminoma vs non-seminoma | seminoma: often present at low age, primarily lymphatic route of spread, radiosensitive non-seminoma: often present at high age, primarily hematogenous route of spread, radioresistant |
| cryptochordism | failure of intra-abdominal testis to descend two phases: transabdominal and inguinosacral (the most common) 75% unilateral increased risk of cancer in both testes |
| hypospadias | congenital defect urethral opening on underside of penis |
| epispadias | congenital defect urethral opening on topside or bottom side of penis |
| phimosis | foreskin can't be retracted fully over glans penis |
| testicular torsion | twisting of spermatic cord venous drainage blocked and increased arterial pressure-->hemorrhagic infarct testis remain viable if untwisted within 6hrs underlying malignancy should always be excluded |
| condyloma | skin disease HPV-related dysplasia: HPV 6 and 11 display koilocytic atypia |
Created by:
kphom001
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