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Biochem 2-1, AA
UMDNJSOM
Question | Answer |
---|---|
All amino acids produce by living systems are called | alpha amino acids. they all have an amino group attached to the alpha carbon |
Enantiomer | alpha-carbon is asymmetric. It is an enantiomer. Stereoisomer that exhibit a property called chirality. Mirror images. |
All protein amino acids are what type of enantiomers | L Enantiomers. amino residue is on the left. Except for glycine. |
Protein turnover | degradation of proteins. continuous process as proteins in the body are constantly replaced. |
Amino Acid Uses in body | Source of nitrogen (75% for proteins, dna/rna, heme, Ach, hormones) and some can be used for energy during starvation. |
Nonpolar aliphatic AA | glycine, alanine, valine, leucine, isoleucine |
Glycine | H, is a D-enantiomer |
Alanine | CH3 |
Valine | CH / \ CH3 CH3 |
Leucine | CH2 CH / \ CH3 CH3 |
Isoleucine | CH- CH3 CH2 CH2 |
Aromatic(hydrophobic) AA | phenylalanine, tryptophan, tyrosine. |
Phenylalanine | CH2 Ph |
Tryptophan | CH2-(2-amino)-cyclopentane-Ph |
Tyrosine | CH2 Ph OH Can form hydrogen bonds through its OH- grouup. Ability often used by cells to carry out protein function. Relatively reactive. |
Positive Charged(Basic) Hydrophilic | Histidine, Lysine, Arginine. Important in electrostatic interactions between substances (ie:dna binding) |
Histidine | CH2 2-4-dinitro-cycolopentane |
Lysine | Ch2 ch2 ch2 ch2 nh3+ |
Arginine | Ch2 ch2 ch2 nh c=NH NH3+ |
Negatively charged(acidic) hydrophilic | Aspartate, glutamate, asparagine, glutamine. |
Aspartate | Ch2 C // \ O O- |
Glutamate | CH2 Ch2 C // \ O O- |
Asparagine | CH2 C // \ O NH2 |
Glutamine | CH2 CH2 C // \ O NH2 |
Hydroxyl Containing AA | Serine/Threonine. Hydrophilic group makes them more hydrophilic and reactive than alanine and valine. OH group hydrogen bonds |
Serine | CH2 OH |
Threonine | CH-OH CH3 |
Cyclic AA | Proline. side chain bonded to both nitrogen and carbon atoms. It is THREE Carbon side chain. Top one bonds to alphacarbon. Bottom one bonds to amino end nitrogen. makes a cyclopentane. |
Sulfur Containing AA | Cysteine and Methionine SH group hydrogen bonds with water |
Cysteine | CH2 SH Important due to ability to form covalent bonds with other cysteine. Disulfide bonds. |
Methionine | CH2 CH2 S CH3 |
Essential Amino Acids | Essential for metabolism, health, growth, not synthesized by the body, must be obtained from food. PVT TIM HALL |