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Rate Limiting Ezymes
USMLE step 1 rate limiting enzymes
| Question | Answer |
|---|---|
| RLS OF Glycolysis converts glucose C6H12O6, into pyruvate | Phosphofructokinase-1 (PFK-1) In Cytosol |
| RLS OF Gluconeogenesis | Fructose-1,6 bisphosphatase In Cytosol |
| RLS OF TCA cycle | Isocitrate Dehydrogenase |
| RLS OF Glycogen Synthesis | Glycogen Synthase |
| RLS OF Glycogenolysis | Glyogen Phosphorylase Deficient in McArle's Disease |
| RLS OF HMP Shunt | Glucose-6-phosphate dehydrogenase (G6PD) |
| RLS OF De Novo Pyrimidine Synthesis Pg 68 | Carbamoyl Phosphate Synthase II (CPS II) |
| Carbamoyl Phosphate Synthase II (CPS II) is done in the? | Cytosol |
| Carbamoyl Phosphate Synthase I is done in the? | Mitochondria |
| RLS OF De Novo Purine Synthesis Pg 68 | Glutamine- PRPP Amidotransferase |
| RLS OF Urea Cycle | Carbamoyl Phosphate Synthase I (CPS I) |
| RLS OF Fatty Acid Synthesis | Acetyl-CoA Carboxylase (ACC) |
| RLS OF Fatty Acid Oxidation | Carnitine Acetyltransferase I |
| RLS OF Ketogenesis | HMG-CoA Synthase |
| RLS OF Cholesterol Synthesis | HMG-CoA Reductase |
| Carbamoyl Phosphate Synthase II (CPS II) is done in the? | Cytosol |
| Carbamoyl Phosphate Synthase I is done in the? | Mitochondria |
| De Novo Purine Synthesis Pg 68 | Glutamine- PRPP Amidotransferase |
| RLS OF Urea Cycle | Carbamoyl Phosphate Synthase I (CPS I) |
| RLS OF Fatty Acid Synthesis | Acetyl-CoA Carboxylase (ACC) |
| RLS OF Fatty Acid Oxidation | Carnitine Acetyltransferase I |
| Ketogenesis | HMG-CoA Synthase |
| RLS OF Cholesterol Synthesis | HMG-CoA Reductase |
| Pyruvate goes to Oxaloacetate by? | Pyruvate carboxylase Need Biotin,ATP, and CO2 (In Mitochondria) Activated by acetyl-CoA |
| Oxaloacetate goes to Phosphoenolpyruvate (PEP) by? | Phosphoenolpyruvate (PEP) Carboxykinase (in Cytosol) Requires GTP |
| Ethanol to Acetaldehyde by? | Alcohol dehydrogenase (inhibited by Fomepizole) (Cytosol) Ethanol to Acetaldehyde = NAD to NADH In the Cytosol |
| Acetaldehyde to Acetate by? | Acetaldehyde Dehydrogenase (inhibited by Disulfram/Antibuse) (mitochondria) NADH increased |
| Fructose to Fructose 1P by? | Fructokinase Using ATP to ADP Deficiency is Essential Frucotosuria |
| Fructose 1p goes to Dihydroxyacetone and Glyceraldehyde by________ which goes to Glyceraldehyde 3-P | Aldolase B Deficiency is Fructose intolerance |
| Galactose goes to Galactitol by? | Aldose reductase (cataracts) |
| Galactose goes to Galactose 1P by? | Galactokinase Using ATP to ADP Deficiency is Galactokinase deficiency |
| Galactose 1-P goes to Glucose 1-p By? | Galactose 1 Phosphate Uridyl Transferase Using UDP-Glu to UDP-Gal (Severe galactosemia) |
| RLS of Heme Synthesis | Aminolevulinic Acid Synthase |
| RLS of Bile Acid Synthesis | 7-Alpha hydroxylase |
| Increase in Glucose 6 Phosphate | von-Gierke's |
| Glucose 6-phosphate to Glucose which happens during Gluconeogenesis Via | Glucose 6 Phosphatase (Von Gierke's) In ER |
| Glucose to Glucose 6 Phosphate via | Hexokinase / Glucokinase In the ER |
| Glucose 6 Phosphate to 6-Phosphogluconolactone via | Glucose 6 Phosphate dehydrogenase (G6PD) |
| Pyruvate goes to Acetyl-Coa via | Pyruvate dehydrogenase |
| Phosphoenolypyruvate goes to Pyruvate in Glycolysis Via | Pyruvate Kinase |
Created by:
Trinimd
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