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Neuro II p33-50
Thomadaki Fall 2010
| Question | Answer |
|---|---|
| What is sound characterized by? | Frequency (pitch) & intensity (volume) |
| Frequency determines ______ and is measured in ____ | pitch, cycles/sec or Hz |
| Range of frequencies audible to humans | 20-20,000Hz or 20Hz to 20kHz |
| Frequency of ULTRASOUND? Heard by who? | >20kHz, animals |
| Frequency of INFRASOUND? heard by who? | <20Hz. Elephants and whales |
| What type of frequencies are implicated in car sickness? | Low frequency sounds |
| 3 functional divisions of the ear? | External, middle, inner era |
| External ear is composed of what two structures? | PINNA (auricle/tragus) - cartilaginous sound capturing convoluted funnel. EXTERNAL ACOUSTIC MEATUS (auditory canal). 2.5 cm tunnel that ends at ear drum |
| What is the middle ear filled with? | Air |
| Middle ear is composed of what 3 structures? | TYMPANIC MEMBRANE (9mm diam conical membrane) OSSICLES (malleus, incus, stapes) TENSOR TYMPANI & STAPEDIUS MUSCLES |
| What is the inner ear filled with? | fluid |
| What 2 structures are found in the inner ear? | COCHLEA (auditory system) - tube that is spiraling 2 1/2x around conical bony modiolus) VESTIBULE |
| What is the function of the middle ear? | Augment sound |
| does the convex/concave portion of tympanic membrane extend into the cavity of the middle ear? | convex |
| What are the ossicles held together by? | synovial membrane |
| What ossicle transfers tympanic membrane displacement to inner ear? | Stapes |
| Middle ear cavity connects to the nasopharynx via the ____, usually closed by a ______ and the _________ via the _____ | Eustachian tube (auditory tube), valve, mastoid air space (antrum), aditus |
| Mastoid air space is AKA? | Antrum |
| Tensor tympani attaches to what ossicle? | Malleus |
| Stapedius attaches to what ossicle? | Stapes |
| Function of the tensor tympani and stapedius? | Make ossicles more rigid in order to dampen v. loud sound |
| TT and stapedius decrease sound by what dB? | 10dB |
| What is the attenuation reflex? | Contracts, tensing up malleus and stapes, dampening loud sound. (doesn't protect from sudden loud sound). |
| What is the delay of the attenuation reflex? | 50-150msecs |
| The middle ear amends the sound so what percentage of waves reach the inner ear? Otherwise, what percent of waves would reach the inner ear? | 67%, 2% |
| The middle ear amplified pressure by ____x? What are the 2 ways it does this? | 22x; (1) surface area of oval window is 17x smaller than that of tympanic mem & (2) ossicles act as levers and increase force output on the oval window (the mvt on footplate of stapes is 1.3x the mvt of the arm of the malleus) |
| What are the two holes in the cochlea called? | oval and round window |
| Fluid movement is created when what happens? | oval window is displaced by stapes. |
| Most of the movements of fluid is absorbed by the fluid of the cochlea but any "unabsorbed" energy does what? | distorts the round window |
| What are the 3 fluid filled chambers of the cochlea? | Scala vestibuli, Scala media, Scala tympani |
| What membrane is located between scala vestibuli and scala media? | Reissner's membrane |
| What membrane is located between scala media and scala tympani? | Basilar membrane. |
| What chambers contain perilymph? | Scalas vestibuli & tympani |
| What two chambers connect? where? | Scalas vestibuli & tympani; Helicotrema |
| Ion concentration of perilymph? | Low K, high Na |
| What chamber contains endolymph? | Scala media (cochlear duct) |
| Ion concentration of endolymph? | High k, low Na |
| What structure is responsible for secreting K while absorbing Na against their concentration gradients? | Stria vascularis |
| Where is the organ of corti located? | On basilar membrane |
| Shape of basilar membrane | Narrow/stiff toward base; wide and floppy at apex |
| Base of basilar membrane codes for what type of frequency? | High frequency |
| Apex of basilar membrane codes for what type of frequency? | Low frequency |
| Arrangement of basilar membrane is called what? | Tonotopic map |
| What is the sensory receptor organ of hearing? | Organ of corti |
| What structures compose the organ of corti? | Inner and outer hair cells, rods of corti (pillar cells) & surrounding cells. |
| Organ of Corti is covered by what? | Tectorial membrane |
| The organ of corti is located where? | In scala medial which contains endolymph |
| Each hair cell has ___ (#?) _____ whose bending causes a _____ | 100 stereocilia; receptor potential |
| There are ______ inner hair cells arranged ______, located between the ____ & _____. | 3500; row; pillar cells & bony modiolus. |
| The stereocilia of the organ of corti extend where? | Into endolymph inferior to tectorial membrane |
| Hair cells synapse with? | Dendrites of bipolar spiral ganglion cells |
| Bipolar spiral ganglion cells are located where? And what do their axons form? | Modiolus; cochlear n. |
| What is the function of hair cells? | Convert mechanical energy that reaches the inner ear to a receptor potential |
| Upward movement of the basilar membrane has what effect? | Causes sterecilia to bend so that K channels on their tips open & depolarize the hair cells. --> causes Ca channels to open --> release of NTs (maybe glutamate) --> synpase between hair cells & dendrites of spiral ganglion |
| Downward movement of basilar membrane has what effect? | Causes hyperpolarization |
| Most of the spiral ganglion cells receive synapses from what type of hair cells? | Inner hair cells |
| Outer hair cells are implicated with what? | Sound amplification (by augmenting the movement of inner hair cells) in inner ear. |
| Ototoxic cells selectively destroy what? | Outer hair cells |
| What forms the cochlear n? | axons of spiral ganglion cells |
| Cochlear n travels where? and synapses with what? | Medulla; cochlear nuclei |
| What are the types of cochlear nuclei? and how many of each? | 2 ventral; 1 dorsal |
| What type of cells do ventral cochlear nuclei have? and what do they do? | Stellate cells; encode a variety of frequencies and bushy cells which fire at onset of sound and aid in localization of sound along horizontal axis |
| What type of cell does dorsal cochlear nucleus have? | fusiform cells; get excited/inhibited by a wide variety of frequencies and aid in sound localization along the vertical axis and tuberculoventral cells that respond with a delay and inhibit echo interference. |
| What is the function of tuberculoventral cells? | Delay and inhibit echo interference |
| Sound localization on vertical axis is controlled by what nucleus? | Ventral cochlear |
| Sound localization on horizontal axis is controlled by what nucleus? | Dorsal cochlear |
| Any injury above cochlear nucleus in auditory pathway leads to hearing loss on what side? | Hearing loss pronounced contralaterally |
| Cochlear nuclei synapse bilaterally with? | superior olivary nuclei |
| medial superior olivary nucleus is involved in localization of sound on ________ by _________ | horizontal axis; processing info about auditory time delay between 2 ears. |
| Interaural time delay is most striking in what frequencies? | low |
| Lateral superior olivary nucleus is involved in localization of sound by ____ | processing intensity difference between the 2 ears |
| Intensity interaural differences are most striking at what frequencies? | High |
| Fibers of superior olivary nucleus form the _______ | lateral lemniscus |
| Some fibers of superior olivary nucleus synapse with nuc of _____ but most synapse with _____ | lateral lemniscus; inferior colliculus |
| Inferior colliculus has 4 layered nucleus which gathers ____ &____ info. And a multi layered nucleus that has a ________ | auditory and somatosensory; tonotopic map |
| What shifts head toward stimulus | tectospinal tract |
| ______ receives info from inferior colliculus via the ______. Holding a _______. Fibers then form the ______ and end in _______ | medial geniculate nuc; inferior brachium; complete somatopic & tonotopic map; auditory radiation; primary auditory cortex |
| Where is the primary auditory cortex? it is _____ organized | Transverse temporal gyri of heschl (41, 42 of brodmann). tonotopically |
| Where is the second point of determining localization of sound source? | Transverse Temporal Gyri of Heschl |
| Conductive hearing loss results from insult to ______. Examples? | middle ear. Otitis media, otosclerosis |
| Sensorineural hearing loss results from injury to ______ there fore loss of ________ | inner ear; cochlear hair cells |
| if person talks very quietly what type of hearing loss might they have? | conductive |
| Weber's test - put tuning fork where? if sound lateralizes ipsilaterally then it's ______ deafness and contralaterally it's ________ deafness | vertex/nasion; conductive; sensorineural |
| Rinne's test - put tuning fork where? | mastoid process, when can't hear sound anymore place it near ear. |
| What type of hearing loss is tested in Rinne's test? | Conductive |
| Inner ear is composed of what 3 structures | Cochlea, Vestibule (utricle & saccule) and semicircular canals |
| The bony labyrinth contains ______, high in what ion? it is continuous with _____? | perilymph, Na, CSF |
| The membranous labyrinth contains ______, high in what ion? | Endolymph, K |
| Vestibular system helps with what 3 things? | Maintenance of posture, muscle tone, eye position with respect to head motion |
| The labyrinth is subdivided into ______ & _______ | static & kinetic labyrinth |
| Static labyrinth is composed of ______ & ______ which has what function? | sacuule & utricle; detects static orientation of head with respect to gravity. |
| What are the specialized hair cells in static labyrinth called? And they are embedded in ______ which contains _______ | macula utricle and macula sacculi; otolithic membrane; CaCO3 crystals |
| Kinetic labyrinth is composed of _______ which have what function? | semicircular canals; detect angular acceleration and deceleration. |
| Semicircular canals are _____ oriented so they can _____ | orthogonally; detect all possible directions of motion. |
| Where are the specialized hair cells in the kinetic labyrinth located? What are they called? and they are embedded in a _______ called _____ | Ampullae; crista ampullaris; gelatinous mass; cupula |
| Transduction of vestibular system - ____ ion influx causes hair cells to _____. When microvilli bend toward kinocilium the cells will ______; when microvilli move away, the cell will ______ | K, depolarize, hyperpolarize |
| Where does the vesitibular nerve enter the brain stem? | cerebellopontine angle lateral to facial n. |
| Where are vestibular nuclei located? | lateral aspect of floor of medullary and pontine part of 4th ventricle - underlying vestibular area |
| Axons from vestibular nuclei project to what 3 areas? | Flocculonodular lobe & fastigial nucleus of cerebellum; spinal cord (vestivulospinal tract); Brainstem nuclei of III, IV and VI bilaterally via MLF |
| Fibers from vestibular nuclei ascend to the ________ nuc --> _______ of cortex | posterior thalamic nuc; parietal association area |
| Internuclear ophthalmoplegia is caused by a lesion to what structure? What are the symptoms? What diseases do you see this? | MLF; Failure of CN III, IV, VI to carry out synchronous horizontal gaze; MS, or vascular d/e |
| Exams for Vestibular system? | BARANY CHAIR - spin around in chair, when stops should have nystagmus CALORIC TESTING: Cold Opposite Warm Same |
| Central lesion to vestibular system leads to what sx? | Nystagmus in various directions in absence of vertigo |
| Peripheral lesion to vestibular system leads to what sx? | Horizontal nystagmus only in presence of vertigo |
| Meniere's Disease. Onset? | idiopathic; dysequilibrium, nystagmus and vertigo coupled with progressive hearing loss and tinnitus. onset age 20-30 |
| Acoustic neuroma - type of tumor? location? May affect what nerves? | schwann cell tumor, usually around IAM or cerebellopontine angle; facial & trigeminal |