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BIOL2083 amino acids
biochemistry
| Term | Definition |
|---|---|
| Alanine | • Ala, A • small • hydrophobic, nonpolar • neutral • R group: methyl |
| Arginine | • Arg, R • large • hydrophilic, polar • basic (+ at physical pH) • R groups: guanadinium (+), hydrocarbon • salt bridges with acidic AAs aspartate + glutamate |
| Asparagine | • Asn, N • small - medium • hydrophilic, polar • no formal charge but has electrical dipole • R group: carboxamide |
| Aspartate | • Asp, D; aka Aspartic acid • small - medium • hydrophilic, polar • acidic (— at physiological pH) • R group: carboxylate (—) |
| Cysteine | • Cys, C • small - medium • hydrophilic, polar • neutral • R group: sulfhydryl (may — into thiolate group, forms disulfide bond with sulfhydryl group of another Cysteine) |
| Glutamine | • Gln, Q • medium • hydrophilic, polar • neutral • R group: carboxamide |
| Glutamate | • Glu, E; aka Glutamic acid • medium • hydrophilic, polar • acidic (— at physiological pH) • R group: carboxylate (—) |
| Glycine | • Gly, G • smallest; only achiral AA, gives flexibility in protein structures • hydrophobic, nonpolar • neutral |
| Histidine | • His, H • medium • hydrophilic, polar • basic (+ at physiological pH) • R group: imidazole ring (+ or — depending on environment, aromatic ring is useful in enzyme active sites) |
| Isoleucine | • Ile, I • medium • hydrophobic, nonpolar • neutral • R group: branched chain aliphatic (branched at beta-C) |
| Leucine | • Leu, L • medium • hydrophobic, nonpolar • neutral • R group: branched chain aliphatic (branched at gamma-C) |
| Lysine | • Lys, K • large • hydrophilic, polar • basic (+ at physiological pH) • R group: terminal amino group (+) |
| Methionine | • Met, M; often first AA in a protein • large • hydrophobic, nonpolar • neutral • R groups: aliphatic chain, thioether group |
| Phenylalanine | • Phe, F • large • hydrophobic, nonpolar • neutral • R group: phenyl ring (aromatic) |
| Proline | • Pro, P; limited rotational flexibility • medium • hydrophobic, nonpolar • neutral • R group: aliphatic side chain (connected between alpha-C and amino N) |
| Serine | • Ser, S • small - medium • hydrophobic, polar • neutral • R group: hydroxyl |
| Threonine | • Thr, T • small - medium • hydrophilic, polar • neutral • R groups: terminal hydroxyl, branched aliphatic (branches at beta-C) |
| Tryptophan | • Trp, W • largest • hydrophobic, nonpolar • neutral • R groups: methylene, indole group (double aromatic ring) |
| Tyrosine | • Tyr, Y • large • hydrophilic, polar • neutral • R groups: phenyl ring (aromatic), hydroxyl (— in certain environments) |
| Valine | • Val, V • small - medium • hydrophobic, nonpolar • neutral • R group: branched aliphatic chain (branched at beta-C) |
| hydrophilic + polar AAs | • Arg, Asn, Asp, Cys, Gln, Glu, His, Lys, Ser, Thr, Tyr |
| hydrophobic + nonpolar AAs | • Ala, Gly, Ile, Leu, Met, Phe, Pro, Trp, Val |
| neutral (at physiological pH) AAs | • may be + or — at extreme pH • Ala, Asn, Cys, Gln, Gly, Ile, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, Val |
| basic (at physiological pH) AAs | • + at physiological pH • Arg, His (depends on environment), Lys |
| acidic (at physiological pH) AAs | • — at physiological pH • Asp (Aspartic acid), Glu (Glutamic acid) |
| AAs with branched aliphatic chain R groups | • Ise (beta-C), Leu (gamma-C), Thr (beta-C), Val (beta-C) |
| AAs with aromatic R groups | • Phe (phenyl ring), Trp (indole double ring), Tyr (phenyl ring) |
| AAs with aliphatic chain (non-branched) R groups | • Met, Pro (connected between alpha-C and amino N) |
| small AAs | • Ala, Gly (smallest) |
| small-medium AAs | • Asn, Asp, Cys, Ser, Thr, Val |
| medium AAs | • Gln, Glu, His, Ile, Leu, Pro |
| large AAs | • Arg, Lys, Met, Phe, Trp (largest), Tyr |