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Immunofluorescence

Detection of antinuclear auto-antibodies

QuestionAnswer
FITC Fluorescein isothiocyanate
What induces autoimmune diseases? Self-reacting antibodies, genetic disposition, hormones, aging, infections, trauma, drugs.
A hallmark of autoimmune diseases? Presence of auto-reactive antibodies directed against antigen(s).
FITC Fluorescein isothiocyanate
SLE Systemic lupus erythematosus
A hallmark of autoimmune diseases? Auto-reactive antibodies that target antigen(s), causing organ or system malfunction.
A standard method for detecting antinuclear autoantibodies? Indirect immunofluorescence
Indirect immunofluorescence materials Tissue sections from rat kidney or liver (antigen). Human serum as primary antibody. Fluorescence labeled or secondary antibody for detection.
What produces different staining patterns? Antinuclear autoantibodies with different nuclear targets
Homogenous nuclear staining is caused by? Targeting of DNA-nucleoprotein histone complexes
Peripheral staining of nuclear membrane is caused by? Antibodies against DNA.
Created by: aliceblank