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Microbiology 1 - Apicomplexz/Sporozoa

Apicomplexa/Sporozoa motility immobile as adults
apicomplexa/sporozoa nutrition parasitic
apicomplexa/sporozoa reproduction 1- binary fission & 2- sexual
species of apicomplexa/sporozoa malaria, toxoplasmosis, babesiosis, cryptosporidium, cyclospora cayentanensis
malaria bad air
malaria discovered by Ross - Nobel Prize in 1902
malaria parasite requires human & mosquito host
in salivary glands of infected mosquito sporozoites & enter human blood to liver
at liver sporozoites become merozoites
after 10 days migrate to blood & attack RBCs & become trophozoites
trophozoites reproduce asexually - producing more merozoites
merozoites released into blood by rupture of RBCs & some merozoites enter sexual reproductive phase & become gametocytes (male & female sex cells)
mosquito takes blood meal takes gametocytes
most gametocytes mature & unite to form zygotes in lining of mosquito's stomach
zygotes pass through stomach wall produce sporozoites - make way to salivary glands
malaria is one of most severe parasitic diseases & world's greatest public health problems
malaria is endemic in tropical areas, millions of deaths
Sickle-cell anemia gene protects people from Malaria
Malaria Sx: high fever, chills b/c of rupture of RBCs in 48-72 hours
1 of 4 species of malarial parasites P. Falciparum
P. Falciparum causes most severe disease - agglutinates RBCs & obstructs blood vessels, causing ischemia
P. Falciparum also causes Black Water Fever
Black Water Fever rapidly fatal disease, RBCs lysed=hemoglobin released & broken down, cause jaundice & kidney damage, pigments from Hb blacken the urine
P. Falciparum Rx: Quinine (a cinchona bark product)
Created by: JYarger
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