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Apicomplexa/Sporozoa
Microbiology 1 - Apicomplexz/Sporozoa
Question | Answer |
---|---|
Apicomplexa/Sporozoa motility | immobile as adults |
apicomplexa/sporozoa nutrition | parasitic |
apicomplexa/sporozoa reproduction | 1- binary fission & 2- sexual |
species of apicomplexa/sporozoa | malaria, toxoplasmosis, babesiosis, cryptosporidium, cyclospora cayentanensis |
malaria | bad air |
malaria discovered by | Ross - Nobel Prize in 1902 |
malaria parasite requires | human & mosquito host |
in salivary glands of infected mosquito | sporozoites & enter human blood to liver |
at liver sporozoites become | merozoites |
after 10 days migrate to blood & attack RBCs & become | trophozoites |
trophozoites reproduce | asexually - producing more merozoites |
merozoites released into | blood by rupture of RBCs & some merozoites enter sexual reproductive phase & become gametocytes (male & female sex cells) |
mosquito takes blood meal | takes gametocytes |
most gametocytes mature & unite to form | zygotes in lining of mosquito's stomach |
zygotes pass through stomach wall | produce sporozoites - make way to salivary glands |
malaria is | one of most severe parasitic diseases & world's greatest public health problems |
malaria is endemic in | tropical areas, millions of deaths |
Sickle-cell anemia gene | protects people from Malaria |
Malaria Sx: | high fever, chills b/c of rupture of RBCs in 48-72 hours |
1 of 4 species of malarial parasites | P. Falciparum |
P. Falciparum causes | most severe disease - agglutinates RBCs & obstructs blood vessels, causing ischemia |
P. Falciparum also causes | Black Water Fever |
Black Water Fever | rapidly fatal disease, RBCs lysed=hemoglobin released & broken down, cause jaundice & kidney damage, pigments from Hb blacken the urine |
P. Falciparum Rx: | Quinine (a cinchona bark product) |