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Microbiology 1 - Rickettsia

Rickettsia Gram (-) coccobacilli bacteria
Rickettsia typical prokaryote
Rickettsia unable to be cultured (except for R. Quintana)
Rickettsia History Identified by Ricketts and Prowazek
Mr. Ricketts 1st identified as causative agents of Rocky Mountain Spotted Fevers & Typhus
Mr. Ricketts & Mr. Prowacek died from accidental contamination
Transmission of Rickettsia via insect (arthropod vector)
Coxiella Burneti transmitted through air
Humans accidental host of Rickettsia, but sole hosts of typhus & trench fever
Rickettsia Vectors Mechanical & Biological
Mechanical Vector Transported by contact; lice acts as this
Biological Vector insect bites a person
Reservoir carries it
Rickettsia transmitted through blood stream
Clinical manifestations of Rickettsia endocarditis, heart valve inflammation, cns damage, kidney, liver & spleen damage, maculopapular rash, inflammed arteries, stupor-suppression of sensory feelings, terminal shock, prostration (exhaustion), necrosis in brain & heart
2 Groups of Rickettsia Typhus & Spotted Fever
Typhus Group grows in cytoplasm
Spotted Fever Group grows in nucleus & cytoplasm
Rickettsia Disease properties invade & damage cells of blood vessel linings, ogan necrosis, skin rash, fever, headache, extreme weakness, liver & spleen enlargement
Defining features of Rickettsia rash & fever
Rickettsia diagnosis Weil Felix Test
Rickettsia treatment Tetracyclin & Chloramphenicol
Treatment only inhibits, does not kill rickettsias
Rickettsia can be latent for 20 years and reactivate
Conditions for Rickettsia spread wars, earthquakes, floods, famines, over crowding, lack of santitation
Created by: JYarger