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Rickettsia
Microbiology 1 - Rickettsia
Question | Answer |
---|---|
Rickettsia | Gram (-) coccobacilli bacteria |
Rickettsia | typical prokaryote |
Rickettsia | unable to be cultured (except for R. Quintana) |
Rickettsia History | Identified by Ricketts and Prowazek |
Mr. Ricketts | 1st identified as causative agents of Rocky Mountain Spotted Fevers & Typhus |
Mr. Ricketts & Mr. Prowacek | died from accidental contamination |
Transmission of Rickettsia | via insect (arthropod vector) |
Coxiella Burneti | transmitted through air |
Humans | accidental host of Rickettsia, but sole hosts of typhus & trench fever |
Rickettsia Vectors | Mechanical & Biological |
Mechanical Vector | Transported by contact; lice acts as this |
Biological Vector | insect bites a person |
Reservoir | carries it |
Rickettsia transmitted through | blood stream |
Clinical manifestations of Rickettsia | endocarditis, heart valve inflammation, cns damage, kidney, liver & spleen damage, maculopapular rash, inflammed arteries, stupor-suppression of sensory feelings, terminal shock, prostration (exhaustion), necrosis in brain & heart |
2 Groups of Rickettsia | Typhus & Spotted Fever |
Typhus Group | grows in cytoplasm |
Spotted Fever Group | grows in nucleus & cytoplasm |
Rickettsia Disease properties | invade & damage cells of blood vessel linings, ogan necrosis, skin rash, fever, headache, extreme weakness, liver & spleen enlargement |
Defining features of Rickettsia | rash & fever |
Rickettsia diagnosis | Weil Felix Test |
Rickettsia treatment | Tetracyclin & Chloramphenicol |
Treatment only | inhibits, does not kill rickettsias |
Rickettsia can be latent for | 20 years and reactivate |
Conditions for Rickettsia spread | wars, earthquakes, floods, famines, over crowding, lack of santitation |