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Block 7- immuno2

Block 7 - immuno words and such from packet 2

QuestionAnswer
B Cell receptor the cell surface-located receptor for antigen on B cell
T cell receptor (TCR) the receptor for antigen on T lymphocytes
Histocompatibility Molecule glycoproteins on surface of cells. Responsible for the compatibility, or lack of it,in tissues of genetically different individuals.
CD4 on surface of T cell. stabilizes TCR-peptide-MHC complext by binding to class II MHC molecule and bring tyrosine kinase into proximity.
T-helper cells T cells with CD4 attached - assist responsiveness of other cells
CD8 on surface of T cell. stabilizes TCR-peptide-MHC complext by binding to class II MHC molecule and bring tyrosine kinase into proximity.
T-cell with CD8 Killing function = lyse virally infected cells
cytotoxic T lymphocyte (CTL) another name for T-cell with CD8
CD3 necessary for a signal to be transduced to the cytoplasm after the TCR binds antigen, thus allowing T-cell activation
Fc receptor in phagocyte surface membrane fraction crystallizable: does not bind antigen, but activates a molecular pathway known as complement and has ability to bind receptors found on macrophages and other cells - so increases likelihood of opsonization
Immune complex lattice of antibody and antigen formed in body
3 different complement pathways classical, lectin, alternative
mannose binding lectin pathway recognizes molecules containing mannose on the surface of bacteria and activates complement cascade
Toll-like receptor (TLR) + phagocytic cell function like pattern recognition molecules to act as pathogen specific molecules such as lipopolysaccharide. binding causes the TLR produce and send signals - cytokines - that alert antigen specific lymphocytes
Pattern recognition molecules (PRM) molecules of the innate immune system capable of recognizing molecules characteric of infection, for example, double-stranded RNA and some sugars
Interleukins 1 protein produced by various cells, including macrophages, interleukin-1 raises body temperature, spurs the production of interferon, and stimulates growth of disease-fighting cells, among other functions. Abbreviated IL-1.
Interleukin 6 IL-6: immune protein,monomer of 184 a.a. produced by T-cells, macrophages, and endothelial cells. Released in response to infection, burns, trauma, and neoplasia, functions: acute-phase protein induction to B- and T- cell growth and differentiation.
Interleukin 8 A cytokine that activates neutrophils and attracts neutrophils and T-lymphocytes. Released by monocytes, macrophages, T-lymphocytes, fibroblasts, endothelial cells, and keratinocytes by an inflammatory stimulus. Il-8 related to platelet factor 4.
Tumor Necrosis Factor Tumor necrosis factor, cytokine produced by monocytes & macrophages. found in synovial cells and macrophages in the tissues. shares properties with interleukin 1. Stimulates IL1 and GM-CSF. Increases tissue damage by IL1.
Created by: El Diablo 7