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Block 7- immuno2
Block 7 - immuno words and such from packet 2
| Question | Answer |
|---|---|
| B Cell receptor | the cell surface-located receptor for antigen on B cell |
| T cell receptor (TCR) | the receptor for antigen on T lymphocytes |
| Histocompatibility Molecule | glycoproteins on surface of cells. Responsible for the compatibility, or lack of it,in tissues of genetically different individuals. |
| CD4 | on surface of T cell. stabilizes TCR-peptide-MHC complext by binding to class II MHC molecule and bring tyrosine kinase into proximity. |
| T-helper cells | T cells with CD4 attached - assist responsiveness of other cells |
| CD8 | on surface of T cell. stabilizes TCR-peptide-MHC complext by binding to class II MHC molecule and bring tyrosine kinase into proximity. |
| T-cell with CD8 | Killing function = lyse virally infected cells |
| cytotoxic T lymphocyte (CTL) | another name for T-cell with CD8 |
| CD3 | necessary for a signal to be transduced to the cytoplasm after the TCR binds antigen, thus allowing T-cell activation |
| Fc receptor in phagocyte surface membrane | fraction crystallizable: does not bind antigen, but activates a molecular pathway known as complement and has ability to bind receptors found on macrophages and other cells - so increases likelihood of opsonization |
| Immune complex | lattice of antibody and antigen formed in body |
| 3 different complement pathways | classical, lectin, alternative |
| mannose binding lectin pathway | recognizes molecules containing mannose on the surface of bacteria and activates complement cascade |
| Toll-like receptor (TLR) + phagocytic cell | function like pattern recognition molecules to act as pathogen specific molecules such as lipopolysaccharide. binding causes the TLR produce and send signals - cytokines - that alert antigen specific lymphocytes |
| Pattern recognition molecules (PRM) | molecules of the innate immune system capable of recognizing molecules characteric of infection, for example, double-stranded RNA and some sugars |
| Interleukins 1 | protein produced by various cells, including macrophages, interleukin-1 raises body temperature, spurs the production of interferon, and stimulates growth of disease-fighting cells, among other functions. Abbreviated IL-1. |
| Interleukin 6 | IL-6: immune protein,monomer of 184 a.a. produced by T-cells, macrophages, and endothelial cells. Released in response to infection, burns, trauma, and neoplasia, functions: acute-phase protein induction to B- and T- cell growth and differentiation. |
| Interleukin 8 | A cytokine that activates neutrophils and attracts neutrophils and T-lymphocytes. Released by monocytes, macrophages, T-lymphocytes, fibroblasts, endothelial cells, and keratinocytes by an inflammatory stimulus. Il-8 related to platelet factor 4. |
| Tumor Necrosis Factor | Tumor necrosis factor, cytokine produced by monocytes & macrophages. found in synovial cells and macrophages in the tissues. shares properties with interleukin 1. Stimulates IL1 and GM-CSF. Increases tissue damage by IL1. |
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El Diablo 7
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