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Autoimmune disorders

PATHO TEST 2

QuestionAnswer
Autoimmune disorders attack "self" cells T cell or Ig-mediated (autoantibodies) Organ-specific or systemic Molecular mimicry: Immune system attacks body cells -Ex: Rheumatic Fever - antistreptococcal antobodies attack heart valves
Systemic Lupus (SLE) Multisystem Disease Antinuclear antibodies (ANAs) Present (elevated 95%) Chronic Disease = remission and exacerbations SKIN RASH- butterfly rash across cheeks Joint inflammation, kidney damage, vasculitis, Raynaud's Phenomenon
SLE Continued Genetics, environment(ebv) and hormonal component diagnosis - history, physical exam, and lab results (11 Criteria)
Sarcoidosis Chronic, multisystem disorder accumulation of T cells and macrophages in organs chronic inflammation = granulomas lungs most frequent place of involvement + skin and eyes Erythema Nodosum; tender, erythematous nodules on anterior legs
SjOgren's Syndrome Kertaconjunctivitis Sicca- Dry eyes Xerostomia- Dry mouth immunological destruction of the lacrimal and salivary glands women more commonly affected(RA)
Scleroderma systemic sclerosis abnormal accumulation of fibrous tissue in skin and organs -gene mutations - Inflammatory rxn w/imjury to endothelium tightening of skin, smooth, shiny, stretched contractures of fingers
CREST (SCLERODERMA) C- calcinosis R- Raynaud's Phenomenon E- Esophageal dysmotility S- Sclerodactyly (shortened muscles) T- Telangiectasia symptoms (spider veins)
Created by: Mplaster
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