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Site of production of chylomicron Small intestine
Site of production of HDL Liver
Site of production of VLDL Liver
Process of atherosclerosis VLDL "loses" triacylglycerols to tissues -> becomes denser (LDL) -> Too much LDL in the blood -> acumulation of LDL in vessels' walls -> attracts WBC -> plaque formation (stenosis) -> calcium coating -> hardening of the vessel -> atherosclerosis
Familial hypercholesterolemia Genetic disorder -> LDL receptors don't function properly -> high LDL levels in the blood
Enzyme responsible for the transference of membrane cholesterol to HDL Flippase
Tangier disease Flippase genetic disorder -> low HDL levels
Transport of cholesterol from intestine to liver Chylomicrons
Transport of cholesterol from liver to tissues VLDL and LDL
Transport of cholesterol from tissues to liver (reverse transport) HDL
Why do atherosclerotic plaques tend to form preferably in the aortic arch? High pressure = increased permeability to macromolecules
Created by: gabrielbianco