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Lipoproteins...
Question | Answer |
---|---|
Site of production of chylomicron | Small intestine |
Site of production of HDL | Liver |
Site of production of VLDL | Liver |
Process of atherosclerosis | VLDL "loses" triacylglycerols to tissues -> becomes denser (LDL) -> Too much LDL in the blood -> acumulation of LDL in vessels' walls -> attracts WBC -> plaque formation (stenosis) -> calcium coating -> hardening of the vessel -> atherosclerosis |
Familial hypercholesterolemia | Genetic disorder -> LDL receptors don't function properly -> high LDL levels in the blood |
Enzyme responsible for the transference of membrane cholesterol to HDL | Flippase |
Tangier disease | Flippase genetic disorder -> low HDL levels |
Transport of cholesterol from intestine to liver | Chylomicrons |
Transport of cholesterol from liver to tissues | VLDL and LDL |
Transport of cholesterol from tissues to liver (reverse transport) | HDL |
Why do atherosclerotic plaques tend to form preferably in the aortic arch? | High pressure = increased permeability to macromolecules |