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Lymphatic System
UCI Histo test 3
Question | Answer |
---|---|
3 purposes of lymphatic system | immune response, maintenance of body fluids, extramedullary heatopoiesis |
lacteals | lymphatic capillaries |
are lymphatic vessels fenestrated? | NO |
flow of lymph | lymphatic capillaries to lymph vessels to lymph nodes to right lymphatic duct or thoracic duct |
what is the largest lymph vessel in body | thoracic duct |
where do the right lymphatic duct and thoracic duct drain | right and left subclavian veins respectively |
structure of lymphatic cappillaries | single layer of attenuated endothelial cells with an incomplete basal lamina |
what is lymphedema | elephantitis |
causes of lymphadema | genetic or injury to lymphatic vessels (surgery, radiation therapy (breast cancer particularly); filariasis; cellulitis |
filariasis | a parasitic infection causing lymphedema |
treatment for lymphedema | decongestive therapy, compression, use of home sequential gradient pumps |
lymphangitis | lymph vessel inflammation (usually streptococcus) from bacterial infection of lymphatic system; can lead to septicemia; can come from tumors, mastectomy, leg vein removal, or tinea pedis (foot fungus infection) |
what do NK cells do | kill tumor cells, virally infected cells, bacteria, and parasites |
which immune system is majorly affect by the lymphoid system | adaptive (innate is not) |
IgD | activates B-cells |
IgE | degranulates mast cells and basophils |
IgG | opsonin, NK cytotoxicity |
primary lymphoid organs | Thymus, prenatal/postnatal bone marrow, fetal liver |
secondary lymphoid organs | lymph nodes, spleen, MALT, postnatal bone marrow |
Encapsulated (dense) lymphatic organs | thymus, lymph nodes, spleen |
unencapsulated (diffuse) lymphatic organs | MALT, BALT, GALT, tonsils |
MALT, BALT, and GALT stand for what | mucosal associated lymphoid tissue, bronchial..., gut... |
function of thymus | immunological competence of T cells, elimination of self-reactive T cells, and MHC (HLA) recognition |
thymic lobes | 2 lobes arising from endoderm and mesoderm |
lobules | incomplete divisions of the lobes formed by septa (trabeculae) |
trabeculae | septa |
thymus capsule | dense collagenous connective tissue covering the thymus |
cortex of thymus | T cell education, elimination of self-reactive T cells, MHC recognition; contains thymocytes, macrophages, and epithelial reticular cells; appears dark due to lots of T cells |
thymocytes | immature T cells in the cortex to be educated |
2 steps of cell instruction in the cortex of thymus | 1)maturation stimulate by hormones produced by epithelial reticular cells 2)testing the ability to recognize self-MHC I/II and self epitopes (mediated by type II/III epithelial reticular cells and bone marrow dendritic APC's |
function of macrophages in cortex | phagocytose apoptosed T cells |
how many lymphocyte clones are formed during embryonic development | 10 quadrillion |
two ways to take out self-reacting t-cells | clonal deletion and anergy (inactivation) |
TCR complex is composed of what | CD3 and either CD4 or CD8 |
medulla of thymus | lightly stained; full of Hassall's corpuscles and immunocompetent T cells |
how do T cells leave medulla | via venules and efferent lymphatic vesseles; migrate to secondary lymphatic structures |
hassall's corpuscles | composed of type VI epithelial reticular cells; increase with age; fxn unknown |
reason for blood-thymus barrier | prevent developing T cells from contacting blood-borne macromolecules |
how does the blood get to the thymus | vessels go through the trabeculae into the corticomedullary jxn, where they form capillary beds that penetrate the cortex |
thymic cappilaries have what three features | a continuous endothelium, a thick basal lamina and adjacent epithelial reticular cells |
what can cross the blood thymus barrier | self-macromolecules to participate in self-recognition of T-cells |
Epithelial reticular cells in the Cortex (Types I-III | Isolate the Cortex of the thymus and prevent maturing T cells / Thymocytes from exposure to foreign antigens. Synthesize hormones (thymosin, serum thymic factor, and thymopoietin) that contribute to thymocyte maturation. |
Epithelial reticular cells in the Medulla (Types IV-VI) | Assist in isolating the Cortex from Medulla (Type IV) to prevent maturing T cells / Thymocytes from exposure to foreign antigens. Type VI form Hassall’s corpuscles. |
Thymic involution | atrophy of the thymus with age |
lymph node size and contents of parenchyma | <3cm; T cells, B cells, APC's and macrophages |
type of lymph vessel valves | semilunar |
flow of lymph in lymph vessels | afferent lymphatic vessels, subcapsular sinuses, cortical sinuses (paratrabecular) which parallel the trabeculae, medullary sinuses, efferent lymphatic vessels |
location and purpose of high endothelial venules in lymph node | in the paracortex; provide acces for lymphocytes to enter lymph node from vascular system |
postcapillary venule location and purpose in lymph node | located in cortex; provide exit for lymphocytes from the lymph node into the vascular system |
lymph node capsule | collagenous connective tissue surrounding lymph node; forms trabeculae upon vagination into lymph node |
lymph node trabeculae | subdivide the outer lymph node cortex into incomplete compartments |
cortex of lymph node | subdivided by trabeculae; houses B cell rich primary and secondary lymphoid nodules |
primary cortical lymphoid nodules | spherical aggregates of virgin and memory B cells in the process of entering/leaving the lymph node |
secondary cortical lymphoid nodules | pale staining and houses a germinal center; form from antigenic challenge, sites of memory B cell and plasma cell generation |
lymph node corona | adjacent to a germinal center; composed of a dense accumulation of lymphocytes migrating away from their site of origin |
dark zone in secondary cortical lymphoid nodules | site of intense B cell proliferation |
light zone in secondary cortical lymphoid nodules | where proliferated B cells migrate, express Igs, do class switching, are exposed to antigen-bearing follicular dendritic cells, and are killed if they fail; survivors exit as memory B's or plasma cells |
paracortex of lymph node | houses T cells (thymus dependent); location of adaptive immune response |
steps of paracortex adaptive immune response | T cells migrate by the HEVs, Dcs/APCs migrate to paracortex to present their epitope-MHC complexes to T-helpers; T-helpers proliferate and expand the paracortex; T-h migrate to medullary sinuses, and exit the node |
medulla of lymph node | large, convoluted lymph sinuses surrounded by lymphoid cells that are organized in clusters called medullary cords |
medullary cords | located in lymph node medulla; contain lymphocytes, plasma cells and macrophages; lymphocytes must go through the medullary sinuses to exit the node via the efferent lymphatic vessels |
fxns of spleen | filter blood, form lymphoid cells, eliminate blood-borne antigens, destroy old platelets and RBCs, fetal hematopoiesis, possible adult hematopoiesis |
capsule, trabeculae, and hilum of spleen | just like the same in the lymph nodes |
function of red pulp of spleen | filter the blood |
components of red pulp of spleen | splenic sinuses and splenic cords of billroth |
white pulp | PALS housing T cells and lymphoid nodules housing H cells |
trabecular arteries in spleen | source of PALS |
PALS | periarterial lymphatic sheath |
trabecular arteries and PALS | trabecular arteries get smaller and smaller until they turn into PALS |
PALS composed of | T cells to watch the blood |
central artery | the vessel occupying the center of the PALS |
penicillar artery | where the central artery terminates it loses its PALS and divides further into a series of short parallel branches, called penicillar arteries, which enter the red pulp |
lymphoid nodules of spleen | found in white pulp; enclosed within the PALS, composed of B cells; displace the central artery to a peripheral position; may display germinal centers, indicating atigenic challenge |
marginal zone in spleen | separates white pulp from red pulp composed of mainly B cells but also plasma cells, T cells, macrophages, and APC; this is the location where APC contact the blood |
Splenic reticular fiber network | attached to the capsule and trabeculae; puts the right type of cells in contact with eachother |
MALT | mucosal associated lymphatic tissue; nonencapsulated lymphoid nodules in the mucosa of th GI, respiratory, and urinary tracts; response to airborne/injected antigens; GALT, BALT, tonsils |
GALT | gut associated lymphatic tissue; composed of B cells surrounded by T cells and APCs; no afferent lymph vessels, but efferent lymph drainage is present |
peyer's patches | GALT in the ileum |
M cells | microfold cells; found in ileum adjacent to peyer's patches; thought to capture antigens and transfer them to macrophages in peyer's patches |
BALT | bronchial associated lymphoid tissues; similar to peyer's patches but in bronchi; no afferent vessels; efferent lymph drainage is present; mostly B cells; M cells are also present |
tonsil | incompletely encapsulated aggregate of lymphoid nodules; mostly T and B lymphocytes |
what are the three tonsils | palatine, pharyngeal, and lingual |
palatine tonsils | composed of lymphoid nodules inside 10-12 crypts, which invaginate the tonsilar parenchyma |
germinal centers are indicative of what and are found where? | indicative of B cell activation by antigen and proliferation; found in tonsil |