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Steroid Hormones

Steroid Hormones - UTSW

What are the 4 types of steroid hormones? adrenal steroids (glucocortocoid, mineralocorticoid), estrogen, progestins, androgen
What 3 classes of enzymes make steroid hormones? cytochrome p450 hydroxylases, hydroxysteroid dehydrogenases, steroid reductases
What are the tissue sites for production of adrenal steroids? zona glomerulosa (aldosterone), zona fasciculata (cortisol), zona reticularis (DHEA & androstenedione)
What type of steroid is aldosterone? mineralocorticoid
What type of steroid is cortisol? glucocorticoid
What type of steroid is DHEA & androstenedione? androgen precursors
Which steroid mediates metabolic, anti-imflammatory & immunosuppressive activities? glucocorticoid
Which steroid promotes Na H20 retention & K execretion? mineralocorticoid
Which steroid is produced in leydig cell of testes & granulosa cells of ovaries? testosterone
Which steroid is produced in the prostate, foreskin, & sebocytes? dihydrotestosterone
Which steroid regulates the growth of internal male genitalia & spermatogenesis? testosterone
Which steroid regulates male external genitalia, male 2ndary characteristics during puberty, and prostate size (also hair loss)? dihydrotestosterone
What is a precursor to both testosterone & estrone? androstenedione
What converts testosterone to estradiol? P450arom
What steroid is produce in the ovaries, testes, adipose tissue, & placenta? estrogen
What steroid prevents bone resorption, keeps HDL levels high, and regulates 2ndary female characteristics? estrogen
What steroid maintains pregnancy & is produced in the corpus luteum? progestin
What organ increases peptide releasing seccretion factor when there is too little steroid? hypothalamus
What organ increase peptide hormone secretion in response to peptide releasing secretion factor? pituitary
How are steroids catabolized? bile acids (urine & feces)
Which steroids are not produced with steroid 21 hydroxylase deficiency? aldosterone & cortisol
What enzyme deficiency causes CAH (congenital adrenal hyperplasia)? steroid 21 hydroxylase deficiency
What are the 3 forms of CAH? salt-wasting, salt-sparing, adult onset
Which form of CAH leads to death in neonates if not treated? salt-wasting
Which form of CAH requires cortisol treatment & surgery? salt-sparing
Which form of CAH requires cortisol treatment & leads to ovary cysts & female hirsutism? adult onset
Which steroid provides feedback inhibition for cortisol & androgen levels? cortisol
What enzyme mutation causes premature baldness? Hyperactive steroid 5α-reductase 2
What enzyme converts testosterone to dihydrotestoterone? steroid 5α-reductase 2
What enzyme mutation leads to male internal genitalia & female external genitalia in an XY phenotype? Hypoactive steroid 5α-reductase 2
Created by: UTSW1