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Steroid Hormones
Steroid Hormones - UTSW
| Question | Answer |
|---|---|
| What are the 4 types of steroid hormones? | adrenal steroids (glucocortocoid, mineralocorticoid), estrogen, progestins, androgen |
| What 3 classes of enzymes make steroid hormones? | cytochrome p450 hydroxylases, hydroxysteroid dehydrogenases, steroid reductases |
| What are the tissue sites for production of adrenal steroids? | zona glomerulosa (aldosterone), zona fasciculata (cortisol), zona reticularis (DHEA & androstenedione) |
| What type of steroid is aldosterone? | mineralocorticoid |
| What type of steroid is cortisol? | glucocorticoid |
| What type of steroid is DHEA & androstenedione? | androgen precursors |
| Which steroid mediates metabolic, anti-imflammatory & immunosuppressive activities? | glucocorticoid |
| Which steroid promotes Na H20 retention & K execretion? | mineralocorticoid |
| Which steroid is produced in leydig cell of testes & granulosa cells of ovaries? | testosterone |
| Which steroid is produced in the prostate, foreskin, & sebocytes? | dihydrotestosterone |
| Which steroid regulates the growth of internal male genitalia & spermatogenesis? | testosterone |
| Which steroid regulates male external genitalia, male 2ndary characteristics during puberty, and prostate size (also hair loss)? | dihydrotestosterone |
| What is a precursor to both testosterone & estrone? | androstenedione |
| What converts testosterone to estradiol? | P450arom |
| What steroid is produce in the ovaries, testes, adipose tissue, & placenta? | estrogen |
| What steroid prevents bone resorption, keeps HDL levels high, and regulates 2ndary female characteristics? | estrogen |
| What steroid maintains pregnancy & is produced in the corpus luteum? | progestin |
| What organ increases peptide releasing seccretion factor when there is too little steroid? | hypothalamus |
| What organ increase peptide hormone secretion in response to peptide releasing secretion factor? | pituitary |
| How are steroids catabolized? | bile acids (urine & feces) |
| Which steroids are not produced with steroid 21 hydroxylase deficiency? | aldosterone & cortisol |
| What enzyme deficiency causes CAH (congenital adrenal hyperplasia)? | steroid 21 hydroxylase deficiency |
| What are the 3 forms of CAH? | salt-wasting, salt-sparing, adult onset |
| Which form of CAH leads to death in neonates if not treated? | salt-wasting |
| Which form of CAH requires cortisol treatment & surgery? | salt-sparing |
| Which form of CAH requires cortisol treatment & leads to ovary cysts & female hirsutism? | adult onset |
| Which steroid provides feedback inhibition for cortisol & androgen levels? | cortisol |
| What enzyme mutation causes premature baldness? | Hyperactive steroid 5α-reductase 2 |
| What enzyme converts testosterone to dihydrotestoterone? | steroid 5α-reductase 2 |
| What enzyme mutation leads to male internal genitalia & female external genitalia in an XY phenotype? | Hypoactive steroid 5α-reductase 2 |
Created by:
UTSW1
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