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Infection Immunity 1
Topic 4 Infection and Immunity
Question | Answer |
---|---|
what's the leading cause of death from infection? | Resp infection 2.74 million death in 2015 |
Where do infectious disease hit the hardest? | Young children in 3rd world countries. |
What are some things that make infectious diseases special? | Reliance of disease on signle agent, transmissibility, potential for unpredictable explosive global impact, derivatin from or evolution in other animals, potential for long-lasting immunity/prevention/eradication |
How many bacteria and bacterial viruses were found per human in Human microbiome project? | 10^14 bacteria and 10^16 bacterial viruses. |
How many bacterial genes reside within us? | >10 mil. |
What did Antoni van Leeuwenhoek do? | invented first microscope, single lens, curvature of water sample acted as second lens. Drew highly accurate drawings of bacteria. |
What is the universla phylogenetic tree based on? | small subunit rRNA sequence - divided into bacteria, archaea, eucarya. |
Why is 16S rRNA used to classify Bacteria? | it is highly conserved between different species of bacteria and archaea |
What are prions? | infectious proteins |
What differs b/w a protazoa and a metazoa? | proto - single cell, meta - tissue differentiation. |
How long ago did microorganisms appear? | about 3.7 billion years ago. |
How do we know that microorganisms lived before the crust was fully stabilised? | element patterns e.g. build up of iron on lake edges. |
What is an obligate anaerobe? | Die from oxyegn. 50% are found in the mouth. |
How many new species of infectious agents evolved since 1977 | 12 |
What did Margaret Chan, director general of WHO, say about antibiotics? | Resistance could bring the end of modern medicine as we know it |
name some bugs already resistant: | Methicillin-res. Staph. aureas; Penicillin-res. pneumococci; VRE; VISA; CRE; Extensively-resistant Mycobact. tuberculosis. |
What are some factors in disease emergence? | adaption to new environment/host, ecological changes, pop growth, human demographics & behaviour, tech & industry, breakdown in public health measures. |