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CH 37 Bordetella

B. pertussis

the causative agent of pertussis (whopping cough) Bordetella pertussis
virulence factors pertussis toxin, filamentous haemagglutinin, pertactin, fimbria, and tracheal cytotoxin
reservoir humans
transmission airborne droplets
B. pertussis virulence factors adhesions (hemagglutins), toxicity, overcoming host defenses
catarrhal mild cold symptoms
paroxysmal severe and violent coughing
convalescent lymphocytosis
collect specimens with swab dacron swab with wire handle
specimen must be taken from areas with ciliated epithelium back of nasopharynx
Bordet-Gengou special cultivation media, potato infusion with sheep blood
plate incubation 35 degrees celcius without CO2
colonial appearance shiny, whitish gray
2 types of acellular vaccines are available DTaP, Tdap
most reliable serology anti-Pertussis toxin (PT)
Created by: nawchem