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CH 37 Bordetella
B. pertussis
the causative agent of pertussis (whopping cough) | Bordetella pertussis |
virulence factors | pertussis toxin, filamentous haemagglutinin, pertactin, fimbria, and tracheal cytotoxin |
reservoir | humans |
transmission | airborne droplets |
B. pertussis virulence factors | adhesions (hemagglutins), toxicity, overcoming host defenses |
catarrhal | mild cold symptoms |
paroxysmal | severe and violent coughing |
convalescent | lymphocytosis |
collect specimens with swab | dacron swab with wire handle |
specimen must be taken from areas with ciliated epithelium | back of nasopharynx |
Bordet-Gengou | special cultivation media, potato infusion with sheep blood |
plate incubation | 35 degrees celcius without CO2 |
colonial appearance | shiny, whitish gray |
2 types of acellular vaccines are available | DTaP, Tdap |
most reliable serology | anti-Pertussis toxin (PT) |