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Antibiotic Classes

Clinical Micro Antibiotcs

QuestionAnswer
How do Sulfonamides act as a competitive antagonist? Sulfonamides are structurally similar to the protein p-aminobenzoic acid, which is essential for bacterial folate synthesis. Sufonamides competitively bind the enzyme that catalyzes folate synthesis, forming non- functional folic acid
What antibiotics/antibiotic classes inhibit protein synthesis? Chloramphenicol, Tetracycline, Macrolides, and Aminoglycosides
What antibiotic is used to treat Pseudomonas? Carbenicillin
What are SXT, Nirtofuradantin, and Nalidixic Acid used to treat and why? Used primarily against UTIs and are completely excreted through the urinary tract with no measurable concentation in serum
What are the aminoglycosides and what issues can they cause? Tobramycin, Gentamicin, Kanamycin, Amikacin, and Streptomycin. They are nephrotoxic and ototoxic.
What is the mode of action of Quinolones and why shouldn't they be given to children under 18? They inhibit DNA synthesis and can interfere with developing bones or cause tendon rupture in children under 18.
What are the Sulfonamides and their alternate names? Gantrisin or Sulfisoxazole Trimethoprim or TMP Sulfamethoxazole or SMX Septra/SXT or Sulfamethoxazole Trimethoprim
What antibiotics interfere with cell wall synthesis? Penicillin, Cephalsporins, and Vancomycin
What is indifference? The combined action of two antibiotics is no greater than that of the more effective antibiotc when used alone (1 + 1 = 1)
Why shouldn't tetracycline be given to pregnant women and children under 8? Tetracycline can permanently discolor developing teeth and bones
Created by: jrzuck