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L30,33 Prot Syn 2/3

USCSOM: Biochemistry: Lec 30, 33 Protein Syn II-III

describe the signal peptide 20-30 AAs; usually at the amino terminus; mostly hydrophobic
Describe SRP signal recognition particle; complex proteins and 7S RNA; halts translation until it is bound to rER surface
Secreted proteins are often stabilized by what? disulfide bonds
Correct formation of disulfide bonds is helped by what enzyme with regards to protein folding in the ER? peptidyl disulfide isomerase
What is the default pathway for a protein without a signal? secretion
What is cotranslational import? uptake of protein into ER depends on continuing protein synthesis by the ribosome
What form of insulin does the insulin gene code for? preproinsulin
What is the single-chain form of insulin called without its signal peptide? proinsulin
What is KDEL? Lys-Asp-Glu-Leu; particular peptide sequence that causes proteins to be captured back from the Golgi
What is the targeting signal for sorting to the lysosome? mannose-6-phosphate
What is the mitochondrial import signal? N-terminal alpha helix with a series of basic AAs on one face
What genes do mitochondrial DNA code for? NADH dehydrogenase, cyto b, cyto oxidase, F1 ATPase
Is uptake into the mitochondrial membrane considered to be pre or post translational? posttranslational
What is the nuclear localization signal? 5-6 AAs; basic and proline
Describe uptake of the protein into the nucleus. pre or post translational? post-translational
What is a common post-translational modification to the N-terminus? removal of methionine and acetylation
What are the two types of post-translational glycosylation? O-linked and N-linked
Describe O-linked post-translational glycosylation covalently bonded to Ser or Thr; one sugar at a time by glycosyltransferases
Describe N-linked post-translational glycosylation linked to Asn; must occur in Asn-Xxx-Ser/Thr sequence;
What is the general peptide sequence for collagen? Gly-X-Y; X= Pro; Y= 4-OHPro
Describe the collagen gene. 50exons; 54bp's and 6GlyXY per base pair
What direction does the collagen triple helix form? C to N-terminus
What intracellular post-translational modifications occur in the formation of collagen? hydroxylations, glycosylations, protofibril formation
What enzyme helps for lysine aldehyde cross links? lysyl oxidase
What is the difference between collagen and procollagen? procollagen still has C and N-propeptides
Describe osteogenesis imperfecta. genetic disorder; characterized by easily breaking bones of varying degree; mutation in type I collagen genes
Created by: jlellerm
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