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Major Players

WVSOM -- Immuno/Micro -- Summary of Major Players

Bone marrow primary site of hematopoiesis; site of B-cell development; site of antibody production
Thymus site of T-cell selection adn development
spleen secondary lympoid tissue; site of antigen recognition and lymphocyte clone proliferation; site of antibody production
lymph nodes secondary lymphoid tissue; site of antigen recognition and lymphocyte clone proliferation; site of antibody production
mucosal lymphatic tissue secondary lymphoid tissue; site of antigen recognition and lymphocyte clone proliferation; site of antibody production
T Cells serve as helper, regulator, killer cells
B cells antibody producting cells (aka plasma cells); also act as anti-gen presenting cells
NK cells natural killer cells that kill tumor cells and virus-infected cells
Antigen-presenting cells present antigenic peptides for T-cell recognition; Dendritic cells, macrophages and B cells
Dendritic cells ubiquitous in tissues and organs; primary APC for naive T-cells
macrophages derived from blood monocytes; highly phagocytic; APC
Neutrophils most abundant leukocyte in blood; phagocytic; primary cell in acute inflammation
Eosinophil normally <3% of blood leukocytes; often increased in allergy and parasitic worm infections
mast cells tissue-resident; release histamine and other pro-inflammatory mediators
Major Histocompatibility complex (MHC) Class I and II molecules; identify "self"; differences in these molecules lead to transplanted organ rejection; primary role is to display antigenic peptides for T-cell recognition
CD molecules A nomenclature system for mainly cell surface proteins that may help classify cell subsets; e.g. CD4 protein identifies helper T cells
Cell Adhesion molecules (CAM) e.g. integrins cell surface molecules that facilitate cell-to-cell signaling; they also play a major role in determining cellular movement and migration
receptors cell-surface glycoproteins that bind specific ligands; e.g., the T-cell receptor which binds specifically to an antigenic peptide; there are also Fc receptors, complement receptors, etc.
Antibody glycoproteins produced by B-cells that bind to antigen; IgA, IgD, IgE, IgG, IgM
cytokines small communication molecules that go between cells
complement plasma proteins that act as opsonins, facilitate inflammation and lysis target microbes
What are the soluble factors? antibodies, cytokines and complement
What are teh cell-surface protiens? MHC, CD molecules, CAM, and receptors
What are teh different cell types? lymphocytes, APC, Neutrophils, eosinophils, mast cells
What are the 3 types of lymphocytes? T cells, B cells and NK cells
What are the 5 organs? bone marrow, thymus, spleen lymph nodes and mucosal lymphatic tissue
CD1 present non-peptide antigens (lipid and glycolipid to some T cells)from dendritic cells and thymocytes
CD 2 Adhesion molecules that binds CD 58 on T cells, thymocytes and NK cells
CD3 Expressed on T cells and thymocytes. Signal transduction by the TCR
CD4 Expressed on T-cell subset, monocytes, Macs. Signals and adheres coreceptors that binds to class II MHC
CD8 expresed by T-cell subset and thymocytes; signaling and adhesion
CD 10 expressed by immature and some mature B-cells; metalloproteinase
CD14 Expressed by monocytes and MACs; binds LPS + LPS-binding protein, Mac activation
CD16a Expressed by NK cells, macs, and mast cells; immune-complex-induced cellular activation; ADCC
CD19 Expressed by most B cells; b cell activation; co-recepotr with CD21 and CD 81
CD20 expressed by all B cells; activates C++ channel and other things unknown
CD 21 Expressed by mature B cells, EDC; receptor for C3d; part of co-receptor with CD19 and CD 81
CD 25 expressed by activated T cells and B cells; It is an IL-2 receptor alpha chain
CD28 expressed by T cells; binds B7-1 and B7-2 as co-stimulator
CD34 Expressed by hematopoietic stem cells; helps with adhesion adn binds to CD62L
CD40 Expressed by B cells, MACs, Dc and endothelium; binds CD40L on T cells to provide T-cell help; Mac activation
CD80 aka B7-1; On APC, binds to CD28 to turn T-cells ON
CD86 aka B7-2;on APC binds to CD 28 to turn T-Cell ON
CD152 aka CTLA-4; on APC binds to CD28 to turn T cells off
CD154 aka CD40 ligand; On T-cell binds to B-cell CD40
Histamine Vasodilate, increase mucus
Prostiglandins vasodilate, increase permeability
Leukotrienes Increase mucus, bronchoconstrict
Chemokines Attract cells to site
Platelet activating factor Chemotaxis, activate PMN (granulocytes)
Enzymatic mediators cell movement, damage and repair of tissue
C3a, C4a increase vasodilation, increase permeability, anaphylatoxin, phaocyte recruitment
C5a increase vasodilation and permeability. Anaphylatoxin, chemotactic factor, phagocyte recruitment
Erythropoietin erytrhocytes
TNF triggers apoptosis, increase CAM fever and cytokines
IL-1 fever, activate endothelium (attract neutrophils)
IL-2 T-cell growth, T%B proliferation, NK proliferation
IL-3 Growth of early hematopoietic progenitor cells
IL-4 made by TH2; B Cell proliferation; IgE production
IL-5 made by TH2 and mast; b cell growth, Antibody secretion, eosinophil activation
IL-6 Fever, acute phase response
IL-8 chemotaxis (recruit neutrophils)
IL-10 made by macrophages and TH2; inhibits macrophage and dendritic cells
IL-12 made by macrophages and dendrites; differentiation of t-cells, increase NK toxins, antiangiogenic, stimulates INF-gamma, TH1 production
IL-17 induces inflammatory cytokines and PMN recruitment
INF-alpha Type I; antiviral
INF-beta Type I; antiviral
INF-gamma type II; macrophage and NK activation, IgG, B and MHC production
G-CSF Stimulates granulocyte adn stem cells
M-CSF stimulates monocytes and macrophages
GM-CSF stimulates granulocytes and monocytes
TGF-beta inhibitory of macrophage T/B; anti-inflammatory, IgA
IgM Complement Activation
IgG Fc receptor-dependent phagocyte responses; complement activation; neonatal immunity (placental transfer)
IgE Immunity against parasites. Environmental allergens. mast cell degranulation (immediate hypersensitivity)
IgA mucosal immunity (transport of IgA thru epithelia
immunoglobulin which is passed thru the placenta IgG 1,2,3 & 4
What are chemokines cause cells to move in a certain direction
IL-13 made by TH2; B Cell proliferation; IgE production
Created by: tjamrose